RFC5

Replication factor C subunit 5 is a protein that in humans is encoded by the RFC5 gene.^[5][6]

RFC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LFS
Identifiers
Aliases	RFC5, RFC36, replication factor C subunit 5
External IDs	OMIM: 600407; MGI: 1919401; HomoloGene: 6730; GeneCards: RFC5; OMA:RFC5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 118,013,588 bp[1] End 118,033,130 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 117,516,168 bp[2] End 117,527,112 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons superior vestibular nucleus body of tongue internal globus pallidus Skeletal muscle tissue of biceps brachii endothelial cell inferior ganglion of vagus nerve Brodmann area 23 subthalamic nucleus right ventricle Top expressed in epiblast embryo bone marrow embryo yolk sac thymus ventricular zone tail of embryo neural tube mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding DNA binding single-stranded DNA helicase activity protein binding ATP binding enzyme binding DNA clamp loader activity Cellular component DNA replication factor C complex Ctf18 RFC-like complex nucleoplasm nucleus Biological process nucleotide-excision repair, DNA gap filling error-free translesion synthesis error-prone translesion synthesis positive regulation of DNA-directed DNA polymerase activity translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision nucleotide-excision repair, DNA incision, 5'-to lesion DNA replication DNA repair telomere maintenance via semi-conservative replication DNA-dependent DNA replication regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5985 72151 Ensembl ENSG00000111445 ENSMUSG00000029363 UniProt P40937 Q9D0F6 RefSeq (mRNA) NM_001130112 NM_001130113 NM_001206801 NM_007370 NM_181578 NM_001346815 NM_028128 RefSeq (protein) NP_001123584 NP_001123585 NP_001193730 NP_001333744 NP_031396 NP_853556 NP_082404 Location (UCSC) Chr 12: 118.01 – 118.03 Mb Chr 5: 117.52 – 117.53 Mb PubMed search [3] [4]
Wikidata
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Function

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[6]

Interactions

RFC5 has been shown to interact with:

• BRD4,^[7]
• CHTF18,^[8]
• PCNA,^[9][10][11]
• RFC2,^[9][12] and
• RFC4.^{[9][12][13][14]}