TRPC5

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene.^[5][6][7] TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.

TRPC5
Identifiers
Aliases	TRPC5, PPP1R159, TRP5, transient receptor potential cation channel subfamily C member 5
External IDs	OMIM: 300334; MGI: 109524; HomoloGene: 74915; GeneCards: TRPC5; OMA:TRPC5 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq23 Start 111,768,011 bp[1] End 112,082,776 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F2|X 65.49 cM Start 143,164,667 bp[2] End 143,471,176 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad prefrontal cortex gastric mucosa ganglionic eminence liver Brodmann area 9 primary visual cortex Hypothalamus right lobe of liver Top expressed in supraoptic nucleus lumbar subsegment of spinal cord dentate gyrus of hippocampal formation granule cell zygote lateral hypothalamus primary visual cortex ventromedial nucleus superior frontal gyrus secondary oocyte dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inositol 1,4,5 trisphosphate binding ion channel activity store-operated calcium channel activity protein binding calcium channel activity clathrin binding actin binding actinin binding ATPase binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane calcium channel complex membrane cytoplasm growth cone soma dendrite membrane raft cation channel complex Biological process manganese ion transport ion transport regulation of cytosolic calcium ion concentration calcium ion transmembrane transport calcium ion transport nervous system development regulation of membrane hyperpolarization positive regulation of peptidyl-threonine phosphorylation positive regulation of axon extension positive regulation of cell population proliferation positive regulation of cytosolic calcium ion concentration neuron differentiation positive regulation of neuron differentiation negative regulation of dendrite morphogenesis transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7224 22067 Ensembl ENSG00000072315 ENSMUSG00000041710 UniProt Q9UL62 Q9QX29 RefSeq (mRNA) NM_012471 NM_009428 RefSeq (protein) NP_036603 NP_033454 Location (UCSC) Chr X: 111.77 – 112.08 Mb Chr X: 143.16 – 143.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

TrpC5 is one of the seven mammalian TRPC (transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na⁺–H⁺ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).^[5]

TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity^[8] and neurological behavior.^[9] It was established in 2021 that TRPC5 is a component of the dental cold sensing system.^[10]

Activation

Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin.^[11] This channel has also been found to be involved in the action of anaesthetics such as chloroform, halothane and propofol.^[12]

Interactions

TRPC5 has been shown to interact with STMN3,^[13] TRPC1,^[14][15] and TRPC4.^[15]

See also

• TRPC