Zyxin

ZYX is a protein that in humans is encoded by the ZYX gene.^[5][6][7]

ZYX
Identifiers
Aliases	ZYX, ESP-2, HED-2, zyxin
External IDs	OMIM: 602002; MGI: 103072; HomoloGene: 31164; GeneCards: ZYX; OMA:ZYX - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 143,381,295 bp[1] End 143,391,111 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B2.1 Start 42,326,564 bp[2] End 42,337,147 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus myometrium left uterine tube granulocyte blood stromal cell of endometrium thoracic aorta right coronary artery ascending aorta smooth muscle tissue Top expressed in granulocyte tail of embryo ascending aorta tibiofemoral joint blood aortic valve tunica media of zone of aorta internal carotid artery external carotid artery lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding RNA binding Cellular component focal adhesion plasma membrane integral component of plasma membrane stress fiber cell junction cytoskeleton nucleus cytoplasm cytosol phagocytic vesicle Biological process cell-cell signaling stress fiber assembly cell adhesion regulation of inflammatory response integrin-mediated signaling pathway cell-matrix adhesion viral process transforming growth factor beta receptor signaling pathway signal transduction cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7791 22793 Ensembl ENSG00000159840 ENSG00000285443 ENSMUSG00000029860 UniProt Q15942 Q62523 RefSeq (mRNA) NM_001010972 NM_003461 NM_001362783 NM_001289617 NM_001289618 NM_001289619 NM_011777 RefSeq (protein) NP_001010972 NP_003452 NP_001349712 NP_001276546 NP_001276547 NP_001276548 NP_035907 Location (UCSC) Chr 7: 143.38 – 143.39 Mb Chr 6: 42.33 – 42.34 Mb PubMed search [3] [4]
Wikidata
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Function

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.^[7]

Interactions

Zyxin has been shown to interact with:

• Actinin, alpha 1^[8][9]
• ENAH,^[10][11]
• LASP1,^[12]
• LATS1,^[13] and
• Vasodilator-stimulated phosphoprotein.^[11][14]