多巴胺受體D2

多巴胺受体D2
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	6CM4
识别号
别名	DRD2；, D2DR, D2R, dopamine receptor D2
外部ID	OMIM：126450 MGI：94924 HomoloGene：22561 GeneCards：DRD2
相关疾病
	重性抑郁障碍
为以下药物的标靶
	remoxipride
	benzquinamide、LP-12、LP-211、LP-44、罗匹尼罗、罗替戈汀、维拉佐酮、7-hydroxy-2-(di-N-propylamino)tetralin、溴隐亭、多巴胺、培高利特、普拉克索、quinelorane、quinpirole、苏马尼罗、阿扑吗啡、阿立哌唑、布瑞哌唑、过乳降、麦角乙脲、吡贝地尔、roxindole、特麦角脲、氨磺必利、布南色林、布他拉莫、氯丙嗪、氯氮平、多潘立酮、eticlopride、三氟噻吨、氟奋乃静、氟哌啶醇、L-741,626、洛沙平、mesoridazine、那法道曲、奥氮平、哌罗匹隆、奋乃静、匹莫齐特、pipotiazine、普乐明、丙嗪、喹硫平、raclopride、利培酮、sertindole、舒必利、levosulpiride、三氟拉嗪、齐拉西酮、zotepine
基因位置（人类）
染色体	11号染色体
终止	113,475,691 bp
基因位置（小鼠）
染色体	小鼠9号染色体
终止	49,319,477 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• protein homodimerization activity; • potassium channel regulator activity; • dopamine neurotransmitter receptor activity, coupled via Gi/Go; • 相同蛋白质结合; • dopamine neurotransmitter receptor activity; • G protein-coupled receptor activity; • 血浆蛋白结合; • signal transducer activity; • adrenergic receptor activity; • dopamine binding; • signaling receptor binding; • ionotropic glutamate receptor binding; • protein heterodimerization activity;
细胞组分	• cytoplasmic vesicle; • sperm flagellum; • endocytic vesicle; • 顶体; • 树突棘; • synaptic vesicle membrane; • 细胞本体; • 细胞膜; • 树突; • ciliary membrane; • 神经末梢; • integral component of membrane; • 突触后致密物质; • 膜; • lateral plasma membrane; • 轴突; • 胞内; • non-motile cilium; • integral component of plasma membrane; • dopaminergic synapse; • glutamatergic synapse; • GABA-ergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
生物学过程	• negative regulation of cell population proliferation; • temperature homeostasis; • adenylate cyclase-inhibiting dopamine receptor signaling pathway; • adenohypophysis development; • circadian regulation of gene expression; • response to toxic substance; • regulation of dopamine secretion; • response to cocaine; • response to amphetamine; • sensory perception of smell; • locomotory behavior; • positive regulation of urine volume; • response to ethanol; • axonogenesis; • response to inactivity; • phospholipase C-activating dopamine receptor signaling pathway; • modulation of chemical synaptic transmission; • 个人仪容; • negative regulation of protein kinase B signaling; • 联想型学习; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • regulation of dopamine uptake involved in synaptic transmission; • regulation of synaptic transmission, GABAergic; • positive regulation of dopamine uptake involved in synaptic transmission; • 信号转导; • Wnt信号通路; • adult walking behavior; • branching morphogenesis of a nerve; • negative regulation of cytosolic calcium ion concentration; • negative regulation of innate immune response; • regulation of phosphoprotein phosphatase activity; • acid secretion; • 进食行为; • positive regulation of G protein-coupled receptor signaling pathway; • response to axon injury; • striatum development; • synaptic transmission, dopaminergic; • nervous system process involved in regulation of systemic arterial blood pressure; • 蠕动; • regulation of long-term neuronal synaptic plasticity; • activation of protein kinase activity; • positive regulation of growth hormone secretion; • regulation of sodium ion transport; • forebrain development; • response to light stimulus; • orbitofrontal cortex development; • 前脉冲抑制; • response to morphine; • response to iron ion; • positive regulation of ERK1 and ERK2 cascade; • 长期记忆; • positive regulation of renal sodium excretion; • negative regulation of insulin secretion; • neuron-neuron synaptic transmission; • intracellular signal transduction; • auditory behavior; • behavioral response to ethanol; • regulation of heart rate; • adenylate cyclase-activating adrenergic receptor signaling pathway; • positive regulation of cytokinesis; • regulation of potassium ion transport; • 色素沉着; • cellular calcium ion homeostasis; • dopamine metabolic process; • response to nicotine; • regulation of MAPK cascade; • response to histamine; • negative regulation of synaptic transmission, glutamatergic; • response to hypoxia; • negative regulation of circadian sleep/wake cycle, sleep; • negative regulation of protein secretion; • synapse assembly; • regulation of locomotion involved in locomotory behavior; • dopamine receptor signaling pathway; • negative regulation of dopamine receptor signaling pathway; • 惊跳反射; • positive regulation of receptor internalization; • protein localization; • arachidonic acid secretion; • positive regulation of transcription by RNA polymerase II; • G protein-coupled receptor internalization; • positive regulation of multicellular organism growth; • positive regulation of long-term synaptic potentiation; • negative regulation of dopamine secretion; • adult behavior; • cerebral cortex GABAergic interneuron migration; • regulation of synapse structural plasticity; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • visual learning; • negative regulation of cell migration; • behavioral response to cocaine; • positive regulation of neuroblast proliferation; • negative regulation of blood pressure; • release of sequestered calcium ion into cytosol; • negative regulation of voltage-gated calcium channel activity; • G protein-coupled receptor signaling pathway; • negative regulation of adenylate cyclase activity; • 兴奋性动作电位; • negative regulation of protein phosphorylation; • 自噬; • positive regulation of neurogenesis; • negative regulation of cell death; • drinking behavior; • adrenergic receptor signaling pathway; • regulation of neurotransmitter uptake; • postsynaptic modulation of chemical synaptic transmission; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
直系同源
	1813
	13489
	ENSG00000149295
	ENSMUSG00000032259
	P14416
	P61168
	NM_016574; NM_000795
	NM_010077
	NP_000786; NP_057658; NP_000786.1
	NP_034207
	维基数据
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多巴胺受体D₂（Dopamine receptor D₂，简称D2R），为翻译自 DRD2 基因的一种多巴胺受体蛋白。D2R最早于1975年为Philip Seeman（英语：Philip Seeman）所发现，并将其命名为“抗精神疾患性多巴胺受体”（antipsychotic dopamine receptor）^[8]。D2R为所有抗精神病药物的作用标的。

事实速览 多巴胺受体D2, 已知的结构 ...

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多巴胺受體D2

功能

同型体

基因组

配体

受体致活剂

部分受体致活剂

受体拮抗剂

别构调控因子

Functionally selective ligands

Protein–protein interactions

Receptor oligomers

注释

参考文献

外部链接

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