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4-HO-DiPT

Chemical compound From Wikipedia, the free encyclopedia

4-HO-DiPT
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4-HO-DiPT, also known as 4-hydroxy-N,N-diisopropyltryptamine or as iprocin, is a synthetic psychedelic drug of the tryptamine family. It is a higher homologue of psilocin and 4-HO-DET and is a positional isomer of 4-HO-DPT.

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Use and dosage

In TiHKAL, Alexander Shulgin reported that 4-HO-DiPT had a dose range of 15 to 20 mg orally and a duration of 2 to 3 hours.[1][2] However, a wider recreational dose range of 3 to 30 mg or more orally has also been reported.[3] The drug is active at around 3 mg and above, and its effects last for 2 to 3 hours.[4] Shulgin has stated that 4-HO-DiPT has an especially steep dose–response curve and narrow dose range, with doses below 10 mg having few to no effects and there having been no trials above 20 mg due to the intensity of its effects.[1]

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Effects

The effects of 4-HO-DiPT are broadly comparable to those of other serotonergic psychedelics such as LSD and psilocin, but they are distinguished by their relative brevity. Shulgin "doubt[s] that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitivity to dose, at least one that is active orally." An idiosyncratic effect of the drug, also noted by Shulgin, is its tendency to induce tremors.[1][5][6]

Some users have reported a minor audio distortion with lower dosages. Higher dosages increase the polarity of the distortion. It is defined as being slightly lower in pitch and creating several different effects, such as pitch bend, volume distortion, and rate distortion. As with most DiPT psychedelics, music can become more dissonant and less harmonious. Users have also reported a visual distortion widely comparable to the hallucinogen LSD.

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Interactions

Pharmacology

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Pharmacodynamics

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4-HO-DiPT acts as an agonist of serotonin receptors, including the serotonin 5-HT2A and 5-HT2B receptors.[7][8][9][10][12] It may also act as a serotonin reuptake inhibitor, although its potency is variable across studies.[7][8][9][10] The drug appears to activate the serotonin 5-HT2C receptor with low potency and much lower than for the serotonin 5-HT2A receptor.[7][8][9][10] Unlike many other tryptamines, 4-HO-DiPT is not a ligand of the rodent trace amine-associated receptor 1 (TAAR1).[7][13]

Pharmacokinetics

The pharmacokinetics of 4-HO-DiPT have been studied.[11]

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Thumb
4-HO-DiPT powder.

Finland

Scheduled in government decree on psychoactive substances banned from the consumer market.[14]

Germany

Scheduled in New Psychoactive Substances Act (NpSG). Use of covered substances is permitted only for industrial and scientific purposes.

Sweden

Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-DiPT as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Mar 1, 2005, in their regulation SFS 2005:26 listed as 4-hydroxi-N,N-diisopropyltryptamin (4-HO-DIPT), making it illegal to sell or possess.[15]

United States

4-HO-DiPT is not scheduled at the federal level in the United States,[16] but it is possible that it could be considered an analog of 5-MeO-DiPT, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.

Florida

"4-Hydroxy-N,N-diisopropyltryptamine" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[17]

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Research

[[File:FT-104 structure.svg|200px|thumb|right|FT-104 ]

Luvesilocin (RE-104, FT-104; O-glutaryl-4-HO-DiPT), a prodrug to 4-HO-DiPT, has entered double blind, randomized, placebo controlled, phase 1 clinical trials in healthy volunteers at the Royal Adelaide Hospital in Australia for the treatment of postpartum depression and treatment-resistant depression. [18][19][20]

References

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