S1PR3

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.^[5]

S1PR3
Identifiers
Aliases	S1PR3, EDG-3, EDG3, LPB3, S1P3, sphingosine-1-phosphate receptor 3
External IDs	OMIM: 601965; MGI: 1339365; HomoloGene: 3829; GeneCards: S1PR3; OMA:S1PR3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.1 Start 88,990,863 bp[1] End 89,005,155 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 51,562,675 bp[2] End 51,576,833 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle decidua cardiac muscle tissue of right atrium ventricular zone right ventricle right coronary artery left coronary artery tail of epididymis Descending thoracic aorta superficial temporal artery Top expressed in internal carotid artery molar left lung lobe external carotid artery dermis epithelium of lens fossa body of femur lumbar spinal ganglion abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity lipid binding integrin binding sphingosine-1-phosphate receptor activity G protein-coupled receptor activity protein binding Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane Biological process Notch signaling pathway signal transduction anatomical structure morphogenesis positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway negative regulation of establishment of endothelial barrier positive regulation of cell population proliferation sphingosine-1-phosphate receptor signaling pathway regulation of interleukin-1 beta production cytokine production inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1903 13610 Ensembl ENSG00000213694 ENSMUSG00000067586 UniProt Q99500 Q9Z0U9 RefSeq (mRNA) NM_005226 NM_010101 RefSeq (protein) NP_005217 NP_034231 Location (UCSC) Chr 9: 88.99 – 89.01 Mb Chr 13: 51.56 – 51.58 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.^[5]

Evolution

Paralogues to S1PR3 Gene^[6]

• S1PR1
• S1PR5
• S1PR2
• S1PR4
• LPAR1
• LPAR3
• LPAR2
• CNR1
• MC5R
• GPR6
• GPR12
• MC4R
• CNR2
• GPR3
• MC3R
• MC2R
• GPR119
• MC1R

See also

• Lysophospholipid receptor