S1PR4

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₄.^[5]

S1PR4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DCO
Identifiers
Aliases	S1PR4, EDG6, LPC1, S1P4, SLP4, sphingosine-1-phosphate receptor 4
External IDs	OMIM: 603751; MGI: 1333809; HomoloGene: 2799; GeneCards: S1PR4; OMA:S1PR4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,172,346 bp[1] End 3,180,332 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 81,333,581 bp[2] End 81,335,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte spleen bone marrow trabecular bone bone marrow cells lymph node upper lobe of left lung right lung Top expressed in granulocyte blood tibiofemoral joint mesenteric lymph nodes spleen bone marrow thymus right lung right lung lobe subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sphingosine-1-phosphate receptor activity G protein-coupled receptor activity signal transducer activity lipid binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane mitochondrion Biological process positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway activation of phospholipase C activity immune response sphingosine-1-phosphate receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8698 13611 Ensembl ENSG00000125910 ENSMUSG00000044199 UniProt O95977 Q9Z0L1 RefSeq (mRNA) NM_003775 NM_010102 RefSeq (protein) NP_003766 NP_034232 Location (UCSC) Chr 19: 3.17 – 3.18 Mb Chr 10: 81.33 – 81.34 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.^[5]

Evolution

Paralogues to S1PR4 Gene^[6]

• S1PR5
• S1PR3
• S1PR1
• S1PR2
• LPAR2
• LPAR1
• LPAR3
• CNR1
• GPR6
• CNR2
• GPR3
• GPR12
• MC4R
• MC5R
• MC3R
• MC2R
• MC1R
• GPR119

See also

• Lysophospholipid receptor