LPAR3

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein in humans that is encoded by the LPAR3 gene.^[5][6] LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[7]

LPAR3
Identifiers
Aliases	LPAR3, EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDs	OMIM: 605106; MGI: 1929469; HomoloGene: 8123; GeneCards: LPAR3; OMA:LPAR3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 84,811,602 bp[1] End 84,893,206 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 H2|3 71.03 cM Start 145,926,718 bp[2] End 145,991,941 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right uterine tube mucosa of paranasal sinus spinal ganglia olfactory zone of nasal mucosa trigeminal ganglion atrium right auricle of heart myocardium cardiac muscle tissue of right atrium Top expressed in lumbar spinal ganglion endocardial cushion right kidney membranous bone Dermatocranium maxilla mandible vestibular membrane of cochlear duct atrioventricular junction atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity lysophosphatidic acid receptor activity G-protein alpha-subunit binding phospholipid binding lipid binding Cellular component integral component of membrane membrane integral component of plasma membrane axon plasma membrane Biological process chemical synaptic transmission positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger bleb assembly positive regulation of collateral sprouting signal transduction positive regulation of MAPK cascade positive regulation of calcium ion transport G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23566 65086 Ensembl ENSG00000171517 ENSMUSG00000036832 UniProt Q9UBY5 Q9EQ31 RefSeq (mRNA) NM_012152 NM_022983 RefSeq (protein) NP_036284 NP_075359 Location (UCSC) Chr 1: 84.81 – 84.89 Mb Chr 3: 145.93 – 145.99 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.^[5]

Evolution

Paralogues

Source:^[8]

• LPAR1
• LPAR2
• S1PR1
• S1PR3
• S1PR4
• S1PR2
• S1PR5
• CNR1
• GPR3
• MC5R
• GPR6
• GPR12
• MC4R
• CNR2
• MC3R
• MC1R
• MC2R
• GPR119

See also

• Lysophospholipid receptor