S1PR2

Protein and coding gene in humans From Wikipedia, the free encyclopedia

S1PR2

Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P2, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).[5]

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S1PR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS1PR2, AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2, DFNB68, sphingosine-1-phosphate receptor 2
External IDsOMIM: 605111; MGI: 99569; HomoloGene: 3118; GeneCards: S1PR2; OMA:S1PR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004230

NM_010333

RefSeq (protein)

NP_004221

NP_034463

Location (UCSC)Chr 19: 10.22 – 10.23 MbChr 9: 20.87 – 20.89 Mb
PubMed search[3][4]
Wikidata
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Function

This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.[5] It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor.[6] S1PR2 is expressed in neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system.[7][8]

Evolution

Paralogues[9]

See also

References

Further reading

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