S1PR2

Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P₂, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).^[5]

S1PR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZTI
Identifiers
Aliases	S1PR2, AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2, DFNB68, sphingosine-1-phosphate receptor 2
External IDs	OMIM: 605111; MGI: 99569; HomoloGene: 3118; GeneCards: S1PR2; OMA:S1PR2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,221,433 bp[1] End 10,231,331 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 7.68 cM Start 20,873,657 bp[2] End 20,888,077 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle vena cava stromal cell of endometrium parotid gland placenta upper lobe of left lung sperm left uterine tube gastric mucosa canal of the cervix Top expressed in decidua efferent ductule vas deferens dermis left lung lobe calvaria otic vesicle abdominal wall tracheobronchial tree lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity lipid binding G protein-coupled receptor binding G protein-coupled receptor activity integrin binding protein binding sphingosine-1-phosphate receptor activity Cellular component membrane integral component of membrane plasma membrane Biological process actin cytoskeleton reorganization positive regulation of establishment of endothelial barrier positive regulation of cell population proliferation G protein-coupled receptor signaling pathway filopodium assembly signal transduction sphingosine-1-phosphate receptor signaling pathway positive regulation of peptidyl-threonine phosphorylation negative regulation of excitatory postsynaptic potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9294 14739 Ensembl ENSG00000267534 ENSMUSG00000043895 UniProt O95136 P52592 RefSeq (mRNA) NM_004230 NM_010333 RefSeq (protein) NP_004221 NP_034463 Location (UCSC) Chr 19: 10.22 – 10.23 Mb Chr 9: 20.87 – 20.89 Mb PubMed search [3] [4]
Wikidata
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Function

This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.^[5] It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor.^[6] S1PR2 is expressed in neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system.^[7][8]

Evolution

Paralogues^[9]

• S1PR1
• S1PR3
• S1PR5
• S1PR4
• LPAR2
• LPAR1
• LPAR3
• CNR1
• GPR6
• MC3R
• GPR12
• GPR3
• MC4R
• MC1R
• CNR2
• MC5R
• MC2R
• GPR119

See also

• Lysophospholipid receptor