GPR12

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.^[5][6][7]

GPR12
Identifiers
Aliases	GPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs	OMIM: 600752; MGI: 101909; HomoloGene: 3868; GeneCards: GPR12; OMA:GPR12 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.13 Start 26,755,200 bp[1] End 26,760,786 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G3 Start 146,519,208 bp[2] End 146,522,049 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence cerebellar hemisphere right hemisphere of cerebellum nucleus accumbens caudate nucleus prefrontal cortex putamen Brodmann area 9 cingulate gyrus anterior cingulate cortex Top expressed in perirhinal cortex entorhinal cortex CA3 field primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell hippocampus proper Region I of hippocampus proper dorsal striatum nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity phosphatidylcholine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway cellular calcium ion homeostasis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2835 14738 Ensembl ENSG00000132975 ENSMUSG00000041468 UniProt P47775 P35412 RefSeq (mRNA) NM_005288 NM_001010941 NM_008151 NM_001359055 NM_001359056 NM_001359057 NM_001359058 RefSeq (protein) NP_005279 NP_001010941 NP_032177 NP_001345984 NP_001345985 NP_001345986 NP_001345987 Location (UCSC) Chr 13: 26.76 – 26.76 Mb Chr 5: 146.52 – 146.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.^[8]

Ligands

Inverse agonists

• Cannabidiol^[9]

Evolution

Paralogues

Source:^[10]

• GPR6
• GPR3
• S1PR5
• CNR1
• CNR2
• MC4R
• S1PR1
• MC3R
• MC2R
• S1PR2
• MC1R
• S1PR3
• LPAR2
• MC5R
• LPAR1
• S1PR4
• LPAR3
• GPR119