ORC5

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.^[5][6][7]

ORC5
Identifiers
Aliases	ORC5, ORC5L, ORC5P, ORC5T, PPP1R117, origin recognition complex subunit 5
External IDs	OMIM: 602331; MGI: 1347044; HomoloGene: 37636; GeneCards: ORC5; OMA:ORC5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1-q22.2 Start 104,126,341 bp[1] End 104,208,047 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 22,691,483 bp[2] End 22,755,427 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell gonad testicle middle temporal gyrus buccal mucosa cell Brodmann area 23 ventricular zone Achilles tendon body of pancreas Top expressed in primary oocyte secondary oocyte zygote spermatocyte epiblast fetal liver hematopoietic progenitor cell primitive streak spermatid endocardial cushion embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding DNA replication origin binding protein binding ATP binding molecular function Cellular component nuclear origin of replication recognition complex origin recognition complex nucleus nucleoplasm cytosol Biological process G1 phase DNA replication DNA replication initiation G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5001 26429 Ensembl ENSG00000164815 ENSMUSG00000029012 UniProt O43913 Q9WUV0 RefSeq (mRNA) NM_001197292 NM_002553 NM_181747 NM_011959 RefSeq (protein) NP_002544 NP_859531 NP_036089 Location (UCSC) Chr 7: 104.13 – 104.21 Mb Chr 5: 22.69 – 22.76 Mb PubMed search [3] [4]
Wikidata
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Function

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and 4L. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[7]

Interactions

ORC5 has been shown to interact with:

• MCM2,^[8]
• MCM3,^[8]
• MCM4,^[8]
• MCM7,^[8]
• ORC1,^[8]
• ORC2,^{[8][9][10][11]}
• ORC3,^{[8][10][11][12]} and
• ORC4.^[8][9][10]