RASSF9

Ras association domain-containing protein 9 (RASSF9), also known as PAM COOH-terminal interactor protein 1 (PCIP1) or peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor (PAMCI) is a protein that in humans is encoded by the RASSF9 gene.^[5]

RASSF9
Identifiers
Aliases	RASSF9, P-CIP1, PAMCI, PCIP1, Ras association domain family member 9
External IDs	OMIM: 610383; MGI: 2384307; HomoloGene: 3976; GeneCards: RASSF9; OMA:RASSF9 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.31 Start 85,800,703 bp[1] End 85,836,409 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D1 Start 102,348,083 bp[2] End 102,385,597 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus bronchial epithelial cell germinal epithelium olfactory zone of nasal mucosa visceral pleura parietal pleura palpebral conjunctiva epithelium of nasopharynx gonad testicle Top expressed in lumbar spinal ganglion spermatid endothelium of vein tooth molar urethra endothelium of artery vasa recta ascending aorta aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding transporter activity Cellular component cytosol endosome trans-Golgi network transport vesicle membrane extracellular exosome recycling endosome Biological process protein targeting signal transduction endosomal transport intracellular transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9182 237504 Ensembl ENSG00000198774 ENSMUSG00000044921 UniProt O75901 Q8K342 RefSeq (mRNA) NM_005447 NM_146240 RefSeq (protein) NP_005438 NP_666352 Location (UCSC) Chr 12: 85.8 – 85.84 Mb Chr 10: 102.35 – 102.39 Mb PubMed search [3] [4]
Wikidata
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Function

RASSF9 the N-terminal RASSF family member Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 12q21.31,^[6][7] is one of two new wild type RASSF9 and RASSF10^[7] proteins. Three proteins that interact with a fragment of the PAM cytosolic domain containing signaling switch I and II the RA1 and RA2ras complex.^[8] RASSF7, the first member of the N-terminal RASSF family is required for mitosis.^[7] RASSF9 is recently found to be involved in regulation of epidermal homeostasis.^[9]

Regulation

The mutant proregion encoding PAM COOH-terminal interactor protein-1 (P-CIP1) is comparable to that of human band 4.1-like TF (blood plasma protein) as a recycling endosomal pathway^[6] in microtubule locations, does NOT bind RasGTP.^[10] Specificity of interaction may all be related to microtubule locations of the endosomal-lysosomal system localized within the centrosome with Transferrin and different Ras proteins or with that one (N-Ras), but on the other hand, it interacts with three^[11] (Ha-Ras, Ki-Ras,^[12] and Rap^[13]) residues function,^[14] blocked by a mutation that affects Ras effector function^[15] is the critical product of the t (6:11) abnormality associated with some human leukemias.^[12] Phosphatidylinositol-3-kinase make contacts with both (6:11) switch I and II^[12] regions of ras^[8] and yeast adenylyl cyclase molecules carrying these mutations are rendered unactivatable by Ras in vitro.^[16] Ras-interacting residues, are appreciably different from that of RalGDS-RBD^[17] through their C-terminal Ras-binding domains (RBD).^[18] Such outliers as afadin/AF-6 and Rin1^[16] were found to inhibit the binding of Raf to Ras.^[14] Adenylyl cyclase molecules carrying these mutations are rendered unactivatable by Ras in vitro with the Ras-associating domain-RA,^[16] not all RA domains bind RasGTP it is a primary Ras-binding site.

Interactions

• PAM Peptidyl-glycine alpha-amidating monooxygenase precursor (PAM)
• RASSF7 Ras association domain-containing protein 7 (HRAS1-related cluster protein 1)
• BLOC1S2 Biogenesis of lysosome-related organelles complex-1 subunit 2 (BLOC subunit 2)
• TF Serotransferrin precursor (Transferrin) (Beta-1-metal- binding globulin)
• RAB11A Ras-related protein Rab-11A^[19]