Nuclear receptor co-repressor 2

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression.^[5][6] NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT)^[5] or T₃ receptor-associating cofactor 1 (TRAC-1).^[6]

NCOR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RT5, 4OAR, 2L5G, 2LTP, 1KKQ, 3R2A, 2ODD, 4A69, 3R29, 1XC5, 1R2B,%%s1KKQ, 1R2B, 1XC5, 2GPV, 2LTP, 3R29, 3R2A, 4A69, 2L5G, 2ODD, 2RT5, 4OAR
Identifiers
Aliases	NCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2
External IDs	OMIM: 600848; MGI: 1337080; HomoloGene: 31370; GeneCards: NCOR2; OMA:NCOR2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 124,324,415 bp[1] End 124,567,589 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.1 Start 125,017,153 bp[2] End 125,179,219 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve anterior pituitary canal of the cervix parotid gland right ovary left ovary left uterine tube body of uterus muscle of thigh right hemisphere of cerebellum Top expressed in superior frontal gyrus muscle of thigh primary visual cortex lip Rostral migratory stream CA3 field ventricular zone genital tubercle dentate gyrus of hippocampal formation granule cell perirhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity protein N-terminus binding histone deacetylase binding Notch binding DNA binding transcription factor binding nuclear receptor binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding sequence-specific DNA binding glucocorticoid receptor binding retinoic acid receptor binding protein-containing complex binding retinoid X receptor binding Cellular component transcription repressor complex nuclear body membrane histone deacetylase complex nuclear matrix nucleoplasm nucleus chromatin Biological process negative regulation of production of miRNAs involved in gene silencing by miRNA regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of lipid metabolic process negative regulation of transcription, DNA-templated negative regulation of androgen receptor signaling pathway lactation response to organonitrogen compound response to estradiol estrous cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9612 20602 Ensembl ENSG00000196498 ENSMUSG00000029478 UniProt Q9Y618 Q9WU42 RefSeq (mRNA) NM_006312 NM_001077261 NM_001206654 NM_001253904 NM_001253905 NM_011424 RefSeq (protein) NP_001070729 NP_001193583 NP_006303 NP_001193583.1 NP_001240833 NP_001240834 NP_035554 Location (UCSC) Chr 12: 124.32 – 124.57 Mb Chr 5: 125.02 – 125.18 Mb PubMed search [3] [4]
Wikidata
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Function

NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains.^[5] NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.^[7]

Family

It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.^[8]

Discovery

SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies.^[5] In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.^[6]

Interactions

Nuclear receptor co-repressor 2 has been shown to interact with:

• AR^[9][10][11]
• BCL6^[12][13][14]
• C-Fos^[15]
• C-jun^[15]
• HDAC1^[16][17]
• HDAC3^{[17][18][19][20][21][22][23]}
• HDAC4^[22][24]
• HDAC5^[24]
• HDAC10^[16]
• MeCP2^[25]
• NR4A1^[26]
• POU2F1^[27]
• PPARD^[28]
• PGR^[29]
• PML^[30][31]
• RBPJ^[32][33]
• RELA^[15][34]
• RUNX1T1^[35][36]
• RARA^[37][38]
• SIN3A^[18][24]
• SNW1^[39][40]
• SPEN^[41]
• SRF^[15]
• TBL1X^{[18][19][20][21]}
• THRB^[42][43][44]
• VDR^[43][45]
• ZBTB16^[12][35][38]