RHOQ

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.^[5][6]

RHOQ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ATX
Identifiers
Aliases	RHOQ, ARHQ, HEL-S-42, RASL7A, TC10, TC10A, ras homolog family member Q
External IDs	OMIM: 605857; MGI: 1931553; HomoloGene: 22704; GeneCards: RHOQ; OMA:RHOQ - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 46,541,806 bp[1] End 46,584,688 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E4|17 56.9 cM Start 87,270,510 bp[2] End 87,307,497 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle right ventricle Achilles tendon Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis vastus lateralis muscle thoracic diaphragm cardiac muscle tissue of right atrium Epithelium of choroid plexus muscle of thigh Top expressed in parotid gland lacrimal gland submandibular gland sternocleidomastoid muscle temporal muscle triceps brachii muscle vastus lateralis muscle ankle digastric muscle atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GBD domain binding profilin binding nucleotide binding GTP binding GTPase activity protein kinase binding Cellular component cytoplasm cytosol membrane plasma membrane actin filament membrane raft Golgi-associated vesicle membrane extracellular exosome intracellular anatomical structure cell cortex cell projection Biological process positive regulation of glucose import insulin receptor signaling pathway regulation of actin cytoskeleton organization regulation of cell shape cellular response to insulin stimulus regulation of small GTPase mediated signal transduction cortical actin cytoskeleton organization positive regulation of filopodium assembly positive regulation of transcription by RNA polymerase II GTP metabolic process small GTPase mediated signal transduction negative regulation of protein localization to plasma membrane endocytosis actin filament organization establishment or maintenance of cell polarity Rho protein signal transduction cell projection assembly actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23433 104215 Ensembl ENSG00000119729 ENSMUSG00000024143 UniProt P17081 Q8R527 RefSeq (mRNA) NM_012249 NM_145491 RefSeq (protein) NP_036381 NP_663466 Location (UCSC) Chr 2: 46.54 – 46.58 Mb Chr 17: 87.27 – 87.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TC10 is a member of the RAS superfamily of small GTP-binding proteins (see HRAS, MIM 190020) involved in insulin-stimulated glucose uptake.[supplied by OMIM]^[6]

In melanocytic cells RHOQ gene expression may be regulated by MITF.^[7]

Interactions

RHOQ has been shown to interact with EXOC7,^[8] GOPC,^[9] PARD6B,^[9][10] WASL,^[11] CDC42EP2,^[12] TRIP10^[13] and CDC42EP3.^[12]