5-HT2A受体

5-HT2A受体
识别号
别名	HTR2A；, 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A
外部ID	OMIM：182135 MGI：109521 HomoloGene：68073 GeneCards：HTR2A
为以下药物的标靶
	LP-12、LP-44、5-carboxamidotryptamine、血清素、5-甲氧基色胺、8-OH-DPAT、AL-37350A、α-methyl-5-HT、阿立哌唑、brl-15572、布苯丙胺、BW-723C86、过乳降、CGS-12066A、2,5-二甲氧基-4-碘代苯丙胺、donitriptan、gr-127935、洛卡色林、LSD、甲基麦角新碱、MK-212、Org 12962、ORG-37684、培高利特、吲哚洛尔、喹硫平、quinpirole、喹哌嗪、ru-24969、sb-216641、N-(3-三氟甲基苯基)哌嗪、色胺、VER-3323、溴隐亭、迈克宁（又译麦角胺）、间氯苯基哌嗪、麦角乙脲、特麦角脲、阿戈美拉汀、阿朴吗啡、布南色林、蟾毒色胺、布他拉莫、cyamemazine、度洛西汀、氟班色林、氟奋乃静、fluspirilene、glemanserin、氟哌啶醇、酮色林、L-741,626、LY215840、mesoridazine、mesulergine、甲麦角林、metitepine、美西麦角、米塞林、米氮平、(±)-molindone、奈法唑酮、奥氮平、奋乃静、匹莫齐特、酰胺哌啶酮、ritanserin、roxindole、RS-102221、RS-127445、sarpogrelate、sb-206553、SB 242084、SB 243213、SDZ SER-082、sertindole、spiperone、spiramide、thioridazine、(Z)-thiothixene、曲唑酮、三氟拉嗪、volinanserin、沃替西汀、呫诺美林、齐拉西酮、zotepine、氯丙嗪、氯氮平、洛沙平、匹莫范色林、利培酮、匹莫齐特、氟哌利多、三氟拉嗪、齐美定、齐拉西酮、裸盖菇素、氯氮平、氟哌啶醇、aripiprazole lauroxil、(Z)-thiothixene、chlorpromazine hydrochloride、cyclobenzaprine hydrochloride、mesoridazine besylate、nefazodone hydrochloride、promazine hydrochloride、quetiapine fumarate、ziprasidone hydrochloride hydrate
基因位置（人类）
染色体	13号染色体
终止	46,897,076 bp
RNA表达模式
	; ;
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基因本体
分子功能	• 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; • G protein-coupled receptor activity; • virus receptor activity; • signal transducer activity; • G-protein alpha-subunit binding; • G protein-coupled serotonin receptor activity; • serotonin binding; • neurotransmitter receptor activity; • 血浆蛋白结合; • 大分子复合物结合;
细胞组分	• 细胞质; • integral component of membrane; • 细胞质基质; • cell projection; • 膜; • cell body fiber; • integral component of plasma membrane; • dendritic shaft; • 轴突; • soma; • caveola; • cytoplasmic vesicle; • 细胞膜; • 树突; • glutamatergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
生物学过程	• detection of mechanical stimulus involved in sensory perception of pain; • release of sequestered calcium ion into cytosol; • regulation of dopamine secretion; • phospholipase C-activating serotonin receptor signaling pathway; • urinary bladder smooth muscle contraction; • positive regulation of MAP kinase activity; • behavioral response to cocaine; • positive regulation of cytosolic calcium ion concentration; • positive regulation of kinase activity; • positive regulation of phosphatidylinositol biosynthetic process; • 老化; • cellular calcium ion homeostasis; • 细胞死亡; • 记忆; • activation of phospholipase C activity; • detection of temperature stimulus involved in sensory perception of pain; • protein localization to cytoskeleton; • 睡眠; • positive regulation of vasoconstriction; • positive regulation of cell population proliferation; • negative regulation of potassium ion transport; • positive regulation of ERK1 and ERK2 cascade; • artery smooth muscle contraction; • positive regulation of peptidyl-tyrosine phosphorylation; • 病毒进入; • phosphatidylinositol 3-kinase signaling; • 痛觉; • temperature homeostasis; • viral process; • positive regulation of fat cell differentiation; • positive regulation of glycolytic process; • negative regulation of synaptic transmission, glutamatergic; • 信号转导; • 化学性突触传递; • serotonin receptor signaling pathway; • phospholipase C-activating G protein-coupled receptor signaling pathway; • G protein-coupled receptor signaling pathway; • 动物行为; • regulation of synaptic vesicle exocytosis; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
	Sources:Amigo / QuickGO
直系同源
	3356
	15558
	ENSG00000102468
	ENSMUSG00000034997
	P28223
	P35363
	NM_001165947; NM_000621; NM_001378924
	NM_172812
	NP_000612; NP_001159419; NP_001365853
	NP_766400
	维基数据
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