LARP4

La-srodni protein 4 je protein koji je kod ljudi kodiran genom LARP4.^[4][5] LARP4 je protein koji se veže za RNK i sastoji se od motiva La (LaM), motiva za prepoznavanje RNK (RRM) i navodnog motiva vezivanja PABP. Pokazano je da je LARP4 uključen u stabilnost iRNK.^[6]

LARP4
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2CQK, 3PKN
Identifikatori
Aliasi	LARP4
Vanjski ID-jevi	MGI: 2443114 HomoloGene: 19173 GeneCards: LARP4
Lokacija gena (miš) Hrom. Hromosom 15 (miš)[1] Bend 15|15 F1 Početak 99,867,946 bp[1] Kraj 99,914,239 bp[1]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • nucleic acid binding • poly(A) binding • vezivanje sa RNK Ćelijska komponenta • membrana • polysome • cytoplasmic stress granule • cytosolic small ribosomal subunit • citoplazma • citosol Biološki proces • regulation of cell morphogenesis • cytoskeleton organization • positive regulation of translation • Biosinteza bjelančevina Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	113251	207214
Ensembl	ENSG00000161813	ENSMUSG00000023025
UniProt	Q71RC2	Q8BWW4
RefSeq (mRNK)	NM_001170803 NM_001170804 NM_001170808 NM_052879 NM_199188 NM_199190 NM_001330415	NM_001024526 NM_001080948 NM_001284521 NM_001284522 NM_001284523
RefSeq (bjelančevina)	NP_001164274 NP_001164275 NP_001164279 NP_001317344 NP_443111 NP_954658 NP_954660 NP_001339233 NP_001339234 NP_001339235 NP_001339236 NP_001339237 NP_001339238 NP_001339239 NP_001339240 NP_001339241 NP_001339242 NP_001339243 NP_001339244 NP_001339245 NP_001339246 NP_001339247 NP_001339248 NP_001339249 NP_001339250 NP_001339251 NP_001339252 NP_001339253 NP_001339254 NP_001339255	NP_001019697 NP_001074417 NP_001271450 NP_001271451 NP_001271452
Lokacija (UCSC)	n/a	Chr 15: 99.87 – 99.91 Mb
PubMed pretraga	[2]	[3]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Poznato je da LARP4 regulira migraciju i invaziju ćelija raka, promjenom njihovog oblika.^[7] Također je objavljeno da je supresorski gen gliomskog tumora.^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 724 aminokiseline, a molekulska težina 80.596 Da.^[9].

10		20		30		40		50
MLLFVEQVAS		KGTGLNPNAK		VWQEIAPGNT		DATPVTHGTE		SSWHEIAATS
GAHPEGNAEL		SEDICKEYEV		MYSSSCETTR		NTTGIEESTD		GMILGPEDLS
YQIYDVSGES		NSAVSTEDLK		ECLKKQLEFC		FSRENLSKDL		YLISQMDSDQ
FIPIWTVANM		EEIKKLTTDP		DLILEVLRSS		PMVQVDEKGE		KVRPSHKRCI
VILREIPETT		PIEEVKGLFK		SENCPKVISC		EFAHNSNWYI		TFQSDTDAQQ
AFKYLREEVK		TFQGKPIMAR		IKAINTFFAK		NGYRLMDSSI		YSHPIQTQAQ
YASPVFMQPV		YNPHQQYSVY		SIVPQSWSPN		PTPYFETPLA		PFPNGSFVNG
FNSPGSYKTN		AAAMNMGRPF		QKNRVKPQFR		SSGGSEHSTE		GSVSLGDGQL
NRYSSRNFPA		ERHNPTVTGH		QEQTYLQKET		STLQVEQNGD		YGRGRRTLFR
GRRRREDDRI		SRPHPSTAES		KAPTPKFDLL		ASNFPPLPGS		SSRMPGELVL
ENRMSDVVKG		VYKEKDNEEL		TISCPVPADE		QTECTSAQQL		NMSTSSPCAA
ELTALSTTQQ		EKDLIEDSSV		QKDGLNQTTI		PVSPPSTTKP		SRASTASPCN
NNINAATAVA		LQEPRKLSYA		EVCQKPPKEP		SSVLVQPLRE		LRSNVVSPTK
NEDNGAPENS		VEKPHEKPEA		RASKDYSGFR		GNIIPRGAAG		KIREQRRQFS
HRAIPQGVTR		RNGKEQYVPP		RSPK

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin