25T-NBOMe

25T-NBOMe
Clinical data
Other names	2C-T-NBOMe; NBOMe-2C-T; N-(2-Methoxybenzyl)-4-methylthio-2,5-dimethoxyphenethylamine
Drug class	Serotonin 5-HT2 receptor agonist; Possible serotonergic psychedelic; Possible hallucinogen
ATC code	None;
Identifiers
	IUPAC name 2-(2,5-dimethoxy-4-methylsulfanylphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine;
CAS Number	1391491-68-1;
PubChem CID	124518722;
ChemSpider	129557542;
Chemical and physical data
Formula	C19H25NO3S
Molar mass	347.47 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC=CC=C1CNCCC2=CC(=C(C=C2OC)SC)OC;
	InChI InChI=1S/C19H25NO3S/c1-21-16-8-6-5-7-15(16)13-20-10-9-14-11-18(23-3)19(24-4)12-17(14)22-2/h5-8,11-12,20H,9-10,13H2,1-4H3; Key:ZWPIZVVOKGWMFW-UHFFFAOYSA-N;

25T-NBOMe, also known as 2C-T-NBOMe or NBOMe-2C-T as well as N-(2-methoxybenzyl)-4-methylthio-2,5-dimethoxyphenethylamine, is a serotonin 5-HT₂ receptor agonist and possible serotonergic psychedelic of the phenethylamine, 2C, and 25-NB (NBOMe) families.^[1]^[2] It is the NBOMe (N-(2-methoxybenzyl)) derivative of 2C-T.^[1]^[2]

Quick Facts Clinical data, Other names ...

Target	Affinity (K_i, nM)
5-HT_1A	ND
5-HT_1B	3,385
5-HT_1D	ND
5-HT_1E	ND
5-HT_1F	ND
5-HT_2A	0.54 (K_i) 2.0–4.2 (EC₅₀Tooltip half-maximal effective concentration) 86–179% (E_maxTooltip maximal efficacy)
5-HT_2B	0.91 (K_i) ND (EC₅₀) ND (E_max)
5-HT_2C	7.4 (K_i) (rat) 21.4 (EC₅₀) 103% (E_max)
5-HT₃	ND
5-HT₄	ND
5-HT_5A	ND
5-HT₆	117
5-HT₇	ND
α_1A–α_1D	ND
α_2A–α_2C	ND
β₁–β₃	ND
D₁–D₅	ND
H₁–H₄	ND
M₁–M₅	ND
I₁	ND
σ₁, σ₂	ND
ORs	ND
TAAR1Tooltip Trace amine-associated receptor 1	ND
SERTTooltip Serotonin transporter	ND (K_i) ND (IC₅₀Tooltip half-maximal inhibitory concentration) ND (EC₅₀)
NETTooltip Norepinephrine transporter	ND (K_i) ND (IC₅₀) ND (EC₅₀)
DATTooltip Dopamine transporter	ND (K_i) ND (IC₅₀) ND (EC₅₀)
Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs: ^[3]^[2]^[4]

Interactions