25T7-NBOMe

25T7-NBOMe, also known as 2C-T-7-NBOMe or NBOMe-2C-T-7 as well as N-(2-methoxybenzyl)-4-propylthio-2,5-dimethoxyphenethylamine, is a serotonergic psychedelic of the 25-NB (NBOMe) family. It is the NBOMe analogue of 2C-T-7. The compound has been sold as a designer drug.^{[2][3][4][5][6]}

25T7-NBOMe

Clinical data
Other names	2C-T-7-NBOMe; NBOMe-2C-T-7; N-(2-Methoxybenzyl)-4-propylthio-2,5-dimethoxyphenethylamine
Drug class	Serotonin 5-HT2 receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code	None
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics)[1]
Identifiers
IUPAC name 2-(2,5-dimethoxy-4-propylsulfanylphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
CAS Number	1539266-55-1 Y
PubChem CID	125181253
CompTox Dashboard (EPA)	DTXSID701342517
Chemical and physical data
Formula	C21H29NO3S
Molar mass	375.53 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCSC1=C(C=C(C(=C1)OC)CCNCC2=CC=CC=C2OC)OC
InChI InChI=1S/C21H29NO3S/c1-5-12-26-21-14-19(24-3)16(13-20(21)25-4)10-11-22-15-17-8-6-7-9-18(17)23-2/h6-9,13-14,22H,5,10-12,15H2,1-4H3 Key:CPVMNHOHOSNFOP-UHFFFAOYSA-N

Use and effects

The active dose range and route of 25T7-NBOMe do not appear to have been described.^[7]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

Pharmacodynamics

25T7-NBOMe activities

Target	Affinity (Ki, nM)
5-HT1A	1,800
5-HT1B	1,902
5-HT1D	2,176
5-HT1E	ND
5-HT1F	ND
5-HT2A	0.68–1.1 (Ki) 7.42–260 (EC50Tooltip half-maximal effective concentration) 41–173% (EmaxTooltip maximal efficacy)
5-HT2B	2.3 (Ki) 310 (EC50) 14% (Emax)
5-HT2C	6.4 (Ki) 19.1 (EC50) 95% (Emax)
5-HT3	ND
5-HT4	ND
5-HT5A	ND
5-HT6	68.8
5-HT7	ND
α1A	340
α1B, α1D	ND
α2A	360
α2B, α2C	ND
β1–β3	ND
D1	4,100
D2	1,000
D3	1,400
D4, D5	ND
H1	1,200
H2–H4	ND
M1–M5	ND
I1	ND
σ1, σ2	ND
ORs	ND
TAAR1Tooltip Trace amine-associated receptor 1	1,000 (Ki) (mouse) 88–90 (Ki) (rat) 2,100 (EC50) (mouse) 550 (EC50) (rat) >10,000 (EC50) (human) 68% (Emax) (mouse) 52% (Emax) (rat)
SERTTooltip Serotonin transporter	3,200 (Ki) 17,000 (IC50Tooltip half-maximal inhibitory concentration) ND (EC50)
NETTooltip Norepinephrine transporter	3,700 (Ki) 34,000 (IC50) ND (EC50)
DATTooltip Dopamine transporter	4,800 (Ki) 55,000 (IC50) ND (EC50)
Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs: [8][9][10][2][3][11]

25T7-NBOMe acts as a highly potent and selective agonist of the serotonin 5-HT₂ receptors.^[2] Its affinities and activities at a variety of other receptors and transporters have also been described.^[2]

History

25T7-NBOMe was first described in the scientific literature by 2012.^[12]

See also

• 25-NB
• 25T-NBOMe
• 25T2-NBOMe
• 25T4-NBOMe