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6-Fluoro-DMT

Chemical compound From Wikipedia, the free encyclopedia

6-Fluoro-DMT
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6-Fluoro-DMT, also known as 6-fluoro-N,N-dimethyltryptamine, is a synthetic serotonin receptor modulator of the tryptamine family.[1][2]

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Effects

6-Fluoro-DMT has been said to not be active as a hallucinogen in humans.[3] It has been claimed that this is due to it being "metabolically blocked", though this was not further elaborated on.[3] In the 1960s, it had been theorized by Stephen Szára and colleagues that psychedelic tryptamines were prodrugs that required 6-hydroxylation to become hallucinogenic, but this theory was later found to be incorrect.[4][5][6][7] 6-Fluoro-DMT has been thought to be inactive as a psychedelic in part because 6-fluoro-DET is inactive in terms of such effects.[8][9][10][11][12]

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Pharmacology

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6-Fluoro-DMT is known to possess varying affinities for serotonin receptors, adrenergic receptors, dopamine receptors, histamine receptors, the imidazoline I1 receptor, sigma receptors, and the serotonin transporter (SERT).[2] It has been found to be a potent partial agonist of the serotonin 5-HT2A receptor and a potent full agonist of the serotonin 5-HT2C receptor.[2] In another study however, it showed affinity for the serotonin 5-HT1A and 5-HT2A receptors but was inactive as a serotonin 5-HT1A receptor agonist and showed low potency as a serotonin 5-HT2A receptor agonist.[14][15] On the other hand, it was only about 3-fold less potent than dimethyltryptamine (DMT) as a serotonin 5-HT2A receptor agonist in this study.[15] 6-Fluoro-DMT is less active than dimethyltryptamine (DMT) in producing effects in animal studies.[1][16]

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History

6-Fluoro was first described in the scientific literature by at least 1966.[1][16][3]

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References

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