Endonuclease/Exonuclease/phosphatase family

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling.^[2]

Endonuclease/Exonuclease/phosphatase family
Structure of the multifunctional DNA-repair enzyme exonuclease III.[1]
Identifiers
Symbol	Exo_endo_phos
Pfam	PF03372
InterPro	IPR005135
PROSITE	PDOC00598
SCOP2	1ako / SCOPe / SUPFAM
OPM superfamily	139
OPM protein	1zwx
CDD	cd08372
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Examples

• AP endonuclease proteins EC 4.2.99.18,
• DNase I proteins EC 3.1.21.1,
• Synaptojanin, an inositol-1,4,5-trisphosphate phosphatase EC 3.1.3.56
• Sphingomyelinase EC 3.1.4.12
• Nocturnin, an NADPH 2' phosphatase^[3]

Subfamilies

• Inositol polyphosphate related phosphatase InterPro: IPR000300

Human proteins containing this domain

2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6; CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D; INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3; SYNJ1; SYNJ2; TTRAP; Nocturnin;