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Enzyme-linked receptor
From Wikipedia, the free encyclopedia
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An enzyme-linked receptor, also known as a catalytic receptor, is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side.[1] Hence a catalytic receptor is an integral membrane protein possessing both catalytic, and receptor functions.[2]
They have two important domains, an extra-cellular ligand binding domain and an intracellular domain, which has a catalytic function; and a single transmembrane helix. The signaling molecule binds to the receptor on the outside of the cell and causes a conformational change on the catalytic function located on the receptor inside the cell.
Examples of the enzymatic activity include:
- Receptor tyrosine kinase, as in fibroblast growth factor receptor. Most enzyme-linked receptors are of this type.[3]
- Serine/threonine-specific protein kinase, as in bone morphogenetic protein
- Guanylate cyclase, as in atrial natriuretic factor receptor
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The following is a list of the five major families of catalytic receptors:
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