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Lysergic acid 2,4-dimethylazetidide
Chemical compound From Wikipedia, the free encyclopedia
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Lysergic acid 2,4-dimethylazetidide (LSZ or LA-SS-Az) is an analog of LSD developed by the team led by David E. Nichols at Purdue University.[2][3] It was developed as a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor. There are three possible stereoisomers around the azetidine ring, with the (S,S)-(+) isomer being the most active, slightly more potent than LSD itself in drug discrimination tests using trained rats.[4]
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There have been several unconfirmed reports of lysergic acid 2,4-dimethylazetidide being synthesized in illicit laboratories and distributed on blotter paper or in liquid solution under names such as "diazedine" and "λ".[5][6]
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Dosage and effects
The dosage of LSZ in humans is said to be 100 to 300 μg orally, which is higher than the listed dosage of LSD (60–200 μg).[7][8] According to David E. Nichols, LSZ is about equipotent with LSD in humans.[9] Hence, unlike in rodents, LSZ does not appear to be more potent than LSD in humans.[7]
Pharmacology
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Perspective
LSZ produces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents.[7] It shows about the same potency as LSD in producing this effect.[7] However, LSZ shows a weaker maximal HTR than LSD or AL-LAD in terms of magnitude.[2] The drug also substitutes for LSD in rodent drug discrimination tests.[7][4] It was about 1.8-fold more potent than LSD in this assay.[7][4]
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History
In 2013, LSZ also appeared on some designer drug and research chemical markets in the United Kingdom.[18] LSZ later gained international popularity through a small cluster of mail-order novel psychedelic shops that appeared in 2012.[19]
Society and culture
Legal status
United Kingdom
On June 10, 2014, the United Kingdom Advisory Council on the Misuse of Drugs (ACMD) recommended that LSZ be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying any harm associated with its use.[18] The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.
Switzerland
LSZ is illegal in Switzerland as of December 2015,[20] in Denmark as of May 2015,[21] and in Sweden as of January 26, 2016.[22]
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See also
References
External links
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