Transmembrane domain of ABC transporters

ABC transporter transmembrane domain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of six alpha helixes that traverse the plasma membrane. Many members of the ABC transporter family (Pfam PF00005) have two such regions.^{[1][2][3][4][5][6]}

ABC transporter transmembrane region
Identifiers
Symbol	ABC_membrane
Pfam	PF00664
InterPro	IPR011527
PROSITE	PDOC00364
SCOP2	1pf4 / SCOPe / SUPFAM
TCDB	3.A.1
OPM superfamily	17
OPM protein	2hyd
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

This family appears to correspond to ABC1 by TCDB classification.

Subfamilies

• Sulphate ABC transporter permease protein 2 InterPro: IPR005667
• Phosphate transport system permease protein 2 InterPro: IPR005672
• Phosphonate uptake transporter InterPro: IPR005769
• Nitrate transport permease InterPro: IPR005889
• NifC-like ABC-type porter InterPro: IPR006469
• Phosphate ABC transporter, permease protein PstC InterPro: IPR011864
• Molybdate ABC transporter, permease protein InterPro: IPR011867
• Nickel ABC transporter, permease subunit NikB InterPro: IPR014156
• Nickel ABC transporter, permease subunit NikC InterPro: IPR014157
• Ectoine/hydroxyectoine ABC transporter, permease protein EhuD InterPro: IPR014341
• Ectoine/hydroxyectoine ABC transporter, permease protein EhuC InterPro: IPR014342

Human proteins containing this domain

ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC12; ABCC13; ABCC2; ABCC3; ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; CFTR; TAP1; TAP2; TAPL;