Prolinom/serinom-bogati upredenozavojnički protein 1 jest protein koji je kod ljudi kodiran genom PSRC1 sa hromosoma 1.[5][6][7]
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Zatvori
Dužina polipeptidnog lanca je 363 aminokiseline, a molekulska težina 38.796 Da.[8]
10 | | 20 | | 30 | | 40 | | 50 |
MEDLEEDVRF | | IVDETLDFGG | | LSPSDSREEE | | DITVLVTPEK | | PLRRGLSHRS |
DPNAVAPAPQ | | GVRLSLGPLS | | PEKLEEILDE | | ANRLAAQLEQ | | CALQDRESAG |
EGLGPRRVKP | | SPRRETFVLK | | DSPVRDLLPT | | VNSLTRSTPS | | PSSLTPRLRS |
NDRKGSVRAL | | RATSGKRPSN | | MKRESPTCNL | | FPASKSPASS | | PLTRSTPPVR |
GRAGPSGRAA | | ASEETRAAKL | | RVSGSGEFVG | | LTLKFLHPSP | | PGPPTPIRSV |
LAPQPSTSNS | | QRLPRPQGAA | | AKSSSQLPIP | | SAIPRPASRM | | PLTSRSVPPG |
RGALPPDSLS | | TRKGLPRPST | | AGHRVRESGH | | KVPVSQRLNL | | PVMGATRSNL |
QPPRKVAVPG | | PTR |
Ovaj gen kodira protein bogat prolinom. Studije srodnog mišjeg gena sugeriraju da je ovaj gen reguliran putem p53 i da može učestvovati u supresiji rasta posredovanoj preko p53. Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[7]
- Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC 2682493. PMID 18193044.
- Wallace C, Newhouse SJ, Braund P, et al. (2008). "Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia". Am. J. Hum. Genet. 82 (1): 139–49. doi:10.1016/j.ajhg.2007.11.001. PMC 2253977. PMID 18179892.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.