Metilosomski protein 50 jest protein koji je kod ljudi kodiran genom WDR77 sa hromosoma 1.[5][6][7]
Kratke činjenice Dostupne strukture, PDB ...
WDR77 |
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Identifikatori |
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Aliasi | WDR77 |
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Vanjski ID-jevi | OMIM: 611734 MGI: 1917715 HomoloGene: 11466 GeneCards: WDR77 |
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Ontologija gena |
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Molekularna funkcija | • methyl-CpG binding • GO:0001948, GO:0016582 vezivanje za proteine • nuclear receptor coactivator activity • protein-arginine N-methyltransferase activity
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Ćelijska komponenta | • citoplazma • citosol • Golđijev aparat • methylosome • nukleoplazma • jedro
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Biološki proces | • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development • negative regulation of epithelial cell proliferation involved in prostate gland development • positive regulation of cell population proliferation • negative regulation of cell population proliferation • peptidyl-arginine N-methylation • positive regulation of nucleic acid-templated transcription • spliceosomal snRNP assembly
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 1: 111.44 – 111.45 Mb | Chr 3: 105.87 – 105.88 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 342 aminokiseline, a molekulska težina 36.724 Da.[8]
10 | | 20 | | 30 | | 40 | | 50 |
MRKETPPPLV | | PPAAREWNLP | | PNAPACMERQ | | LEAARYRSDG | | ALLLGASSLS |
GRCWAGSLWL | | FKDPCAAPNE | | GFCSAGVQTE | | AGVADLTWVG | | ERGILVASDS |
GAVELWELDE | | NETLIVSKFC | | KYEHDDIVST | | VSVLSSGTQA | | VSGSKDICIK |
VWDLAQQVVL | | SSYRAHAAQV | | TCVAASPHKD | | SVFLSCSEDN | | RILLWDTRCP |
KPASQIGCSA | | PGYLPTSLAW | | HPQQSEVFVF | | GDENGTVSLV | | DTKSTSCVLS |
SAVHSQCVTG | | LVFSPHSVPF | | LASLSEDCSL | | AVLDSSLSEL | | FRSQAHRDFV |
RDATWSPLNH | | SLLTTVGWDH | | QVVHHVVPTE | | PLPAPGPASV | | TE |
Pokazalo se da protein 77 koji sadrži ponavljanje WD reagira sa CTDP1[9] i enzimom protein arginin-metiltransferaza 5.[5]
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
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- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Licciardo P, Amente S, Ruggiero L, et al. (2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
- Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. doi:10.1016/j.febslet.2004.12.045. PMID 15670829.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Furuno K, Masatsugu T, Sonoda M, et al. (2006). "Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro". Biochem. Biophys. Res. Commun. 345 (3): 1051–8. doi:10.1016/j.bbrc.2006.05.014. PMID 16712789.
- Zhou L, Wu H, Lee P, Wang Z (2007). "Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells". J. Mol. Endocrinol. 37 (2): 283–300. doi:10.1677/jme.1.02062. PMID 17032745.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Liang JJ, Wang Z, Chiriboga L, et al. (2007). "The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors". J. Urol. 177 (5): 1918–22. doi:10.1016/j.juro.2007.01.017. PMID 17437848.