ACVRL1

ACVRL1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2LCR, 3MY0, 4FAO
Identifikatori
Aliasi	ACVRL1
Vanjski ID-jevi	OMIM: 601284 MGI: 1338946 HomoloGene: 20058 GeneCards: ACVRL1
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	51,923,361 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	101,043,217 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • nucleotide binding; • protein kinase activity; • activin binding; • transforming growth factor beta-activated receptor activity; • vezivanje iona metala; • kinase activity; • protein serine/threonine kinase activity; • transmembrane receptor protein serine/threonine kinase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • BMP receptor activity; • ATP binding; • protein kinase binding; • transforming growth factor beta binding; • transforming growth factor beta receptor activity, type I; • activin receptor activity, type I; • SMAD binding; • growth factor binding;
Ćelijska komponenta	• integral component of membrane; • membrana; • integral component of plasma membrane; • soma; • dendrit; • ćelijska membrana; • cell surface; • receptor complex; • activin receptor complex;
Biološki proces	• cellular response to transforming growth factor beta stimulus; • negative regulation of cell adhesion; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of endothelial cell differentiation; • positive regulation of endothelial cell proliferation; • blood vessel morphogenesis; • negative regulation of blood vessel endothelial cell migration; • lymphangiogenesis; • regulation of DNA replication; • Fosforilacija; • endothelial tube morphogenesis; • retina vasculature development in camera-type eye; • wound healing, spreading of epidermal cells; • lymphatic endothelial cell differentiation; • positive regulation of pathway-restricted SMAD protein phosphorylation; • cellular response to BMP stimulus; • negative regulation of endothelial cell differentiation; • in utero embryonic development; • blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • Krvotok; • positive regulation of angiogenesis; • venous blood vessel development; • negative regulation of endothelial cell migration; • negative regulation of endothelial cell proliferation; • regulation of blood vessel endothelial cell migration; • regulation of blood pressure; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • protein phosphorylation; • blood vessel remodeling; • negative regulation of cell migration; • transmembrane receptor protein serine/threonine kinase signaling pathway; • negative regulation of cell growth; • positive regulation of chondrocyte differentiation; • Angiogeneza; • artery development; • regulation of endothelial cell proliferation; • positive regulation of BMP signaling pathway; • transforming growth factor beta receptor signaling pathway; • negative regulation of focal adhesion assembly; • negative regulation of DNA biosynthetic process; • GO:0072468 Transdukcija signala; • negative regulation of cell population proliferation; • blood vessel maturation; • activin receptor signaling pathway; • response to hypoxia; • endocardial cushion to mesenchymal transition; • endocardial cushion morphogenesis; • negative regulation of gene expression; • dorsal aorta morphogenesis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • BMP signaling pathway; • pattern specification process;
	Izvori:Amigo / QuickGO
Ortolozi
	94
	11482
	ENSG00000139567
	ENSMUSG00000000530
	P37023
	Q61288
	NM_000020; NM_001077401
	NM_001277255; NM_001277257; NM_001277258; NM_001277259; NM_009612
	NP_000011; NP_001070869
	NP_001264184; NP_001264186; NP_001264187; NP_001264188; NP_033742
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Receptor R3 serin/treonin-protein kinaze je enzim koji je kod ljudi kodiran genom ACVRL1.^[5]^[6]^[7]

Kratke činjenice Dostupne strukture, PDB ...

ACVRL1 je receptor u signalnom putu TGF-beta. Poznat je i kao aktivinska receptoolika kinaza 1 ili ALK1.

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10	20	30	40	50
MTLGSPRKGL	LMLLMALVTQ	GDPVKPSRGP	LVTCTCESPH	CKGPTCRGAW
CTVVLVREEG	RHPQEHRGCG	NLHRELCRGR	PTEFVNHYCC	DSHLCNHNVS
LVLEATQPPS	EQPGTDGQLA	LILGPVLALL	ALVALGVLGL	WHVRRRQEKQ
RGLHSELGES	SLILKASEQG	DSMLGDLLDS	DCTTGSGSGL	PFLVQRTVAR
QVALVECVGK	GRYGEVWRGL	WHGESVAVKI	FSSRDEQSWF	RETEIYNTVL
LRHDNILGFI	ASDMTSRNSS	TQLWLITHYH	EHGSLYDFLQ	RQTLEPHLAL
RLAVSAACGL	AHLHVEIFGT	QGKPAIAHRD	FKSRNVLVKS	NLQCCIADLG
LAVMHSQGSD	YLDIGNNPRV	GTKRYMAPEV	LDEQIRTDCF	ESYKWTDIWA
FGLVLWEIAR	RTIVNGIVED	YRPPFYDVVP	NDPSFEDMKK	VVCVDQQTPT
IPNRLAADPV	LSGLAQMMRE	CWYPNPSARL	TALRIKKTLQ	KISNSPEKPK
VIQ

ACVRL1

Aminokiselinska sekvenca

Funkcija

Patologija

Kao cilj lijekova

Bliske/porodično-srodne kinaze

Također pogledajte

Reference

Dopunska literatura

Vanjski linkovi

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