CCL3

CCL3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR
Identifikatori
Aliasi	CCL3
Vanjski ID-jevi	OMIM: 182283 MGI: 98260 HomoloGene: 88430 GeneCards: CCL3
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	36,090,169 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	83,540,181 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein kinase activity; • cytokine activity; • CCR5 chemokine receptor binding; • chemokine activity; • CCR1 chemokine receptor binding; • kinase activity; • phospholipase activator activity; • calcium-dependent protein kinase C activity; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje identičnih proteina; • chemoattractant activity; • CCR chemokine receptor binding;
Ćelijska komponenta	• citoplazma; • citosol; • intracellular anatomical structure; • extracellular region; • Vanćelijsko;
Biološki proces	• G protein-coupled receptor signaling pathway; • signaling; • negative regulation of bone mineralization; • positive regulation of protein kinase B signaling; • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; • response to cholesterol; • positive regulation of calcium-mediated signaling; • regulation of sensory perception of pain; • protein kinase B signaling; • monocyte chemotaxis; • negative regulation of osteoclast differentiation; • astrocyte cell migration; • positive regulation of cell migration; • positive regulation of natural killer cell chemotaxis; • chemokine-mediated signaling pathway; • T cell chemotaxis; • cell-cell signaling; • cellular response to tumor necrosis factor; • eosinophil chemotaxis; • GO:1904579 cellular response to organic cyclic compound; • cellular calcium ion homeostasis; • negative regulation of gene expression; • neutrophil chemotaxis; • cell activation; • MAPK cascade; • Hemotaksija; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • positive regulation of neuron apoptotic process; • positive regulation of calcium ion import; • macrophage chemotaxis; • GO:1901313 positive regulation of gene expression; • cytoskeleton organization; • osteoblast differentiation; • cellular response to interleukin-1; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell shape; • positive regulation of tumor necrosis factor production; • cellular response to interferon-gamma; • lymphocyte chemotaxis; • inflammatory response; • granulocyte chemotaxis; • response to toxic substance; • eosinophil degranulation; • lipopolysaccharide-mediated signaling pathway; • calcium ion transport; • calcium-mediated signaling; • Egzocitoza; • positive regulation of calcium ion transport; • positive chemotaxis; • positive regulation of inflammatory response; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • regulation of behavior; • positive regulation of microglial cell activation; • positive regulation of microglial cell migration;
	Izvori:Amigo / QuickGO
Ortolozi
	6348
	20302
	ENSG00000278567; ENSG00000277632; ENSG00000274221
	ENSMUSG00000000982
	P10147
	P10855
	NM_002983
	NM_011337
	NP_002974
	NP_035467
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hemokinski (C-C motivni) ligand 3 (CCL3), znan i kao makrofagni upalni protein 1-alfa (MIP-1-alfa) je protein koji je kod ljudi kodiran genom CCL.^[5]