DRD4

DRD4
Identifikatori
Aliasi	DRD4
Vanjski ID-jevi	OMIM: 126452 MGI: 94926 HomoloGene: 20215 GeneCards: DRD4
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	640,706 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	140,876,377 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• signal transducer activity; • potassium channel regulator activity; • SH3 domain binding; • vezivanje identičnih proteina; • dopamine neurotransmitter receptor activity; • G protein-coupled receptor activity; • GO:0001948, GO:0016582 vezivanje za proteine; • dopamine binding; • dopamine neurotransmitter receptor activity, coupled via Gi/Go; • epinephrine binding; • norepinephrine binding; • vezivanje iona metala; • G protein-coupled serotonin receptor activity; • neurotransmitter receptor activity;
Ćelijska komponenta	• integral component of membrane; • integral component of plasma membrane; • membrana; • ćelijska membrana; • postsynapse; • glutamatergic synapse; • dendrit;
Biološki proces	• response to amphetamine; • rhythmic process; • arachidonic acid secretion; • regulation of circadian rhythm; • positive regulation of dopamine uptake involved in synaptic transmission; • GO:0072468 Transdukcija signala; • fear response; • dopamine metabolic process; • behavioral response to ethanol; • behavioral response to cocaine; • positive regulation of sodium:proton antiporter activity; • cellular calcium ion homeostasis; • positive regulation of kinase activity; • adult locomotory behavior; • inhibitory postsynaptic potential; • negative regulation of protein secretion; • socijalno ponašanje; • negative regulation of voltage-gated calcium channel activity; • regulation of dopamine metabolic process; • response to histamine; • behavioral fear response; • dopamine receptor signaling pathway; • G protein-coupled receptor signaling pathway; • adenylate cyclase-inhibiting dopamine receptor signaling pathway; • regulation of postsynaptic neurotransmitter receptor internalization; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • chemical synaptic transmission; • G protein-coupled serotonin receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	1815
	13491
	ENSG00000069696; ENSG00000276825
	ENSMUSG00000025496
	P21917
	P51436
	NM_000797
	NM_007878
	NP_000788
	NP_031904
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Dopaminski receptor D₄ je dopaminski D2-liki G-protein spregnuti receptor koji je kodiran genom DRD4 sa hromosoma 11, regija 11p15.5.^[5]

Kratke činjenice Identifikatori, Aliasi ...

Nedavno je objavljena struktura DRD4 u kombinaciji s antipsihotskim lijekom nemonaprid.^[6]

Kao i kod drugih podtipova dopaminskih receptora, receptor D₄ aktivira neurotransmiter dopamin. Povezan je s mnogim neurvnim i psihijatrijskim stanjima ^[7] uključujući shizofreniju i bipolarni poremećaj,^[8] ADHD,^[9]^[10] addiktivna ponašanja,^[11] Parkinsnsonovu bolest,^[12] i poremećaj ishrane kao što je anoreksija nervoza.^[13] Nađena je slaba povezanost između DRD4 i graničnog poremećaja ličnosti.

Također je meta lijekova koji liječe shizofreniju i Parkinsonovu bolest.^[14] Receptor D₄ smatra se sličnim D₂, u kojem aktivirani receptor inhibira enzim adenilat-ciklaza, čime se smanjuje unutarćelijska koncentracija drugog glasnika cAMPa.^[15]

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10	20	30	40	50
MGNRSTADAD	GLLAGRGPAA	GASAGASAGL	AGQGAAALVG	GVLLIGAVLA
GNSLVCVSVA	TERALQTPTN	SFIVSLAAAD	LLLALLVLPL	FVYSEVQGGA
WLLSPRLCDA	LMAMDVMLCT	ASIFNLCAIS	VDRFVAVAVP	LRYNRQGGSR
RQLLLIGATW	LLSAAVAAPV	LCGLNDVRGR	DPAVCRLEDR	DYVVYSSVCS
FFLPCPLMLL	LYWATFRGLQ	RWEVARRAKL	HGRAPRRPSG	PGPPSPTPPA
PRLPQDPCGP	DCAPPAPGLP	RGPCGPDCAP	AAPGLPPDPC	GPDCAPPAPG
LPQDPCGPDC	APPAPGLPRG	PCGPDCAPPA	PGLPQDPCGP	DCAPPAPGLP
PDPCGSNCAP	PDAVRAAALP	PQTPPQTRRR	RRAKITGRER	KAMRVLPVVV
GAFLLCWTPF	FVVHITQALC	PACSVPPRLV	SAVTWLGYVN	SALNPVIYTV
FNAEFRNVFR	KALRACC

DRD4

Aminokiselinska sekvenca

Genetika

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Reference

Vanjski linkovi

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