EPHA2

EPHA2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1MQB, 2E8N, 2K9Y, 2KSO, 2X10, 2X11, 3C8X, 3CZU, 3FL7, 3HEI, 3HPN, 3KKA, 3MBW, 3MX0, 3SKJ, 4P2K, 4PDO, 4TRL, 5EK7
Identifikatori
Aliasi	EPHA2
Vanjski ID-jevi	OMIM: 176946 MGI: 95278 HomoloGene: 20929 GeneCards: EPHA2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	16,156,069 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	141,056,695 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • protein kinase activity; • aktivnost sa transferazom; • kinase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • protein tyrosine kinase activity; • ATP binding; • ephrin receptor activity; • transmembrane receptor protein tyrosine kinase activity; • cadherin binding; • virus receptor activity; • transmembrane-ephrin receptor activity;
Ćelijska komponenta	• integral component of membrane; • projekcija ćelije; • membrana; • ruffle membrane; • međućelijske veze; • lamellipodium membrane; • leading edge membrane; • focal adhesion; • integral component of plasma membrane; • intracellular anatomical structure; • ćelijska membrana; • lamellipodium; • cell surface; • neuron projection; • receptor complex; • tight junctions;
Biološki proces	• regulation of lamellipodium assembly; • skeletal system development; • negative regulation of protein kinase B signaling; • Ćelijska diferencijacija; • regulation of cell adhesion mediated by integrin; • protein kinase B signaling; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • Fosforilacija; • transmembrane receptor protein tyrosine kinase signaling pathway; • keratinocyte differentiation; • Vaskulogeneza; • multicellular organism development; • protein phosphorylation; • Ćelijska adhezija; • blood vessel development; • notochord morphogenesis; • notochord cell development; • Angiogeneza; • intrinsic apoptotic signaling pathway in response to DNA damage; • neural tube development; • neuron differentiation; • Notohord; • regulation of ERK1 and ERK2 cascade; • cell chemotaxis; • post-anal tail morphogenesis; • axial mesoderm formation; • response to growth factor; • GO:0022415 viral process; • Ćelijska migracija; • GO:0097285 apoptoza; • peptidyl-tyrosine phosphorylation; • osteoclast differentiation; • osteoblast differentiation; • regulation of angiogenesis; • regulation of blood vessel endothelial cell migration; • ephrin receptor signaling pathway; • lens fiber cell morphogenesis; • mammary gland epithelial cell proliferation; • bone remodeling; • branching involved in mammary gland duct morphogenesis; • GO:0032697 negative regulation of cytokine production; • GO:0051637 defense response to Gram-positive bacterium; • negative regulation of lymphangiogenesis; • blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • pericyte cell differentiation; • negative regulation of angiogenesis; • inflammatory response; • negative regulation of chemokine production; • blood vessel morphogenesis; • cAMP metabolic process; • cell motility; • viral entry into host cell; • positive regulation of protein localization to plasma membrane; • axon guidance; • protein localization to plasma membrane; • positive regulation of bicellular tight junction assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	1969
	13836
	ENSG00000142627
	ENSMUSG00000006445
	P29317
	Q03145
	NM_004431; NM_001329090
	NM_010139
	NP_001316019; NP_004422
	NP_034269
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

EPH-receptor A2 (efrinski receptor 2 tip-A ) jest protein koji je kod ljudi kodiran genom EPHA2 sa hromosoma 1.^[5]^[6]

Kratke činjenice Dostupne strukture, PDB ...

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10	20	30	40	50
MELQAARACF	ALLWGCALAA	AAAAQGKEVV	LLDFAAAGGE	LGWLTHPYGK
GWDLMQNIMN	DMPIYMYSVC	NVMSGDQDNW	LRTNWVYRGE	AERIFIELKF
TVRDCNSFPG	GASSCKETFN	LYYAESDLDY	GTNFQKRLFT	KIDTIAPDEI
TVSSDFEARH	VKLNVEERSV	GPLTRKGFYL	AFQDIGACVA	LLSVRVYYKK
CPELLQGLAH	FPETIAGSDA	PSLATVAGTC	VDHAVVPPGG	EEPRMHCAVD
GEWLVPIGQC	LCQAGYEKVE	DACQACSPGF	FKFEASESPC	LECPEHTLPS
PEGATSCECE	EGFFRAPQDP	ASMPCTRPPS	APHYLTAVGM	GAKVELRWTP
PQDSGGREDI	VYSVTCEQCW	PESGECGPCE	ASVRYSEPPH	GLTRTSVTVS
DLEPHMNYTF	TVEARNGVSG	LVTSRSFRTA	SVSINQTEPP	KVRLEGRSTT
SLSVSWSIPP	PQQSRVWKYE	VTYRKKGDSN	SYNVRRTEGF	SVTLDDLAPD
TTYLVQVQAL	TQEGQGAGSK	VHEFQTLSPE	GSGNLAVIGG	VAVGVVLLLV
LAGVGFFIHR	RRKNQRARQS	PEDVYFSKSE	QLKPLKTYVD	PHTYEDPNQA
VLKFTTEIHP	SCVTRQKVIG	AGEFGEVYKG	MLKTSSGKKE	VPVAIKTLKA
GYTEKQRVDF	LGEAGIMGQF	SHHNIIRLEG	VISKYKPMMI	ITEYMENGAL
DKFLREKDGE	FSVLQLVGML	RGIAAGMKYL	ANMNYVHRDL	AARNILVNSN
LVCKVSDFGL	SRVLEDDPEA	TYTTSGGKIP	IRWTAPEAIS	YRKFTSASDV
WSFGIVMWEV	MTYGERPYWE	LSNHEVMKAI	NDGFRLPTPM	DCPSAIYQLM
MQCWQQERAR	RPKFADIVSI	LDKLIRAPDS	LKTLADFDPR	VSIRLPSTSG
SEGVPFRTVS	EWLESIKMQQ	YTEHFMAAGY	TAIEKVVQMT	NDDIKRIGVR
LPGHQKRIAY	SLLGLKDQVN	TVGIPI

EPHA2

Amiokiselininska sekvenca

Funkcija

Klinički značaj

Interakcije

Reference

Dopunska literatura

Vanjski linkovi

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