FLT1

Receptor 1 vaskularnog endotelnog faktora rasta je protein koji je kod ljudi kodiran genom FLT1.^[5]

FLT1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG, 4CKV, 4CL7, 5EX3
Identifikatori
Aliasi	FLT1
Vanjski ID-jevi	OMIM: 165070 MGI: 95558 HomoloGene: 134179 GeneCards: FLT1
Lokacija gena (čovjek) Hrom. Hromosom 13 (čovjek)[1] Bend 13q12.3 Početak 28,300,346 bp[1] Kraj 28,495,145 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5 G3|5 87.01 cM Početak 147,498,414 bp[2] Kraj 147,662,821 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vascular endothelial growth factor-activated receptor activity • aktivnost sa transferazom • nucleotide binding • protein kinase activity • placental growth factor-activated receptor activity • kinase activity • GO:0001948, GO:0016582 vezivanje za proteine • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • growth factor binding • vascular endothelial growth factor binding Ćelijska komponenta • citoplazma • integral component of membrane • endozom • focal adhesion • membrana • receptor complex • integral component of plasma membrane • extracellular region • Vanćelijsko • ćelijska membrana • actin cytoskeleton Biološki proces • positive regulation of vascular endothelial growth factor receptor signaling pathway • Ćelijska diferencijacija • blood vessel morphogenesis • vascular endothelial growth factor receptor-1 signaling pathway • positive regulation of MAP kinase activity • monocyte chemotaxis • positive regulation of phospholipase C activity • transmembrane receptor protein tyrosine kinase signaling pathway • vascular endothelial growth factor signaling pathway • Fosforilacija • positive regulation of angiogenesis • positive regulation of phosphatidylinositol 3-kinase activity • multicellular organism development • Hemotaksija • protein phosphorylation • vascular endothelial growth factor receptor signaling pathway • embryonic morphogenesis • Angiogeneza • protein autophosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • cellular response to vascular endothelial growth factor stimulus • Ćelijska migracija • positive regulation of MAPK cascade • positive regulation of cell population proliferation • positive regulation of cell migration • sprouting angiogenesis • positive regulation of ERK1 and ERK2 cascade • negative regulation of vascular endothelial cell proliferation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2321	14254
Ensembl	ENSG00000102755	ENSMUSG00000029648
UniProt	P17948	P35969
RefSeq (mRNK)	NM_001159920 NM_001160030 NM_001160031 NM_002019	NM_010228 NM_001363135
RefSeq (bjelančevina)	NP_001153392 NP_001153502 NP_001153503 NP_002010	NP_034358 NP_001350064
Lokacija (UCSC)	Chr 13: 28.3 – 28.5 Mb	Chr 5: 147.5 – 147.66 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.338 aminokiselina, a molekulska težina 150 769 Da .^[6]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MVSYWDTGVL		LCALLSCLLL		TGSSSGSKLK		DPELSLKGTQ		HIMQAGQTLH
LQCRGEAAHK		WSLPEMVSKE		SERLSITKSA		CGRNGKQFCS		TLTLNTAQAN
HTGFYSCKYL		AVPTSKKKET		ESAIYIFISD		TGRPFVEMYS		EIPEIIHMTE
GRELVIPCRV		TSPNITVTLK		KFPLDTLIPD		GKRIIWDSRK		GFIISNATYK
EIGLLTCEAT		VNGHLYKTNY		LTHRQTNTII		DVQISTPRPV		KLLRGHTLVL
NCTATTPLNT		RVQMTWSYPD		EKNKRASVRR		RIDQSNSHAN		IFYSVLTIDK
MQNKDKGLYT		CRVRSGPSFK		SVNTSVHIYD		KAFITVKHRK		QQVLETVAGK
RSYRLSMKVK		AFPSPEVVWL		KDGLPATEKS		ARYLTRGYSL		IIKDVTEEDA
GNYTILLSIK		QSNVFKNLTA		TLIVNVKPQI		YEKAVSSFPD		PALYPLGSRQ
ILTCTAYGIP		QPTIKWFWHP		CNHNHSEARC		DFCSNNEESF		ILDADSNMGN
RIESITQRMA		IIEGKNKMAS		TLVVADSRIS		GIYICIASNK		VGTVGRNISF
YITDVPNGFH		VNLEKMPTEG		EDLKLSCTVN		KFLYRDVTWI		LLRTVNNRTM
HYSISKQKMA		ITKEHSITLN		LTIMNVSLQD		SGTYACRARN		VYTGEEILQK
KEITIRDQEA		PYLLRNLSDH		TVAISSSTTL		DCHANGVPEP		QITWFKNNHK
IQQEPGIILG		PGSSTLFIER		VTEEDEGVYH		CKATNQKGSV		ESSAYLTVQG
TSDKSNLELI		TLTCTCVAAT		LFWLLLTLFI		RKMKRSSSEI		KTDYLSIIMD
PDEVPLDEQC		ERLPYDASKW		EFARERLKLG		KSLGRGAFGK		VVQASAFGIK
KSPTCRTVAV		KMLKEGATAS		EYKALMTELK		ILTHIGHHLN		VVNLLGACTK
QGGPLMVIVE		YCKYGNLSNY		LKSKRDLFFL		NKDAALHMEP		KKEKMEPGLE
QGKKPRLDSV		TSSESFASSG		FQEDKSLSDV		EEEEDSDGFY		KEPITMEDLI
SYSFQVARGM		EFLSSRKCIH		RDLAARNILL		SENNVVKICD		FGLARDIYKN
PDYVRKGDTR		LPLKWMAPES		IFDKIYSTKS		DVWSYGVLLW		EIFSLGGSPY
PGVQMDEDFC		SRLREGMRMR		APEYSTPEIY		QIMLDCWHRD		PKERPRFAEL
VEKLGDLLQA		NVQQDGKDYI		PINAILTGNS		GFTYSTPAFS		EDFFKESISA
PKFNSGSSDD		VRYVNAFKFM		SLERIKTFEE		LLPNATSMFD		DYQGDSSTLL
ASPMLKRFTW		TDSKPKASLK		IDLRVTSKSK		ESGLSDVSRP		SFCHSSCGHV
SEGKRRFTYD		HAELERKIAC		CSPPPDYNSV		VLYSTPPI

Funkcija

Onkogen FLT pripada porodici src gena i srodan je onkogenu ROS (MIM 165020). Kao i drugi članovi ove porodice, pokazuje aktivnost tirozinske protein-kinaze, koja je važna za kontrolu proliferacije i diferencijacije ćelija. Struktura sekvence gena FLT nalikuje strukturi gena FMS (MIM 164770); stoga, Yoshida et al. (1987) predložili su naziv FLT kao akronim za FMS-sličnu tirozin-kinazu.^[7]

Nedavno je otkriveno da je ablacija VEGFR1 hemijskim i genetičkim putem povećala pretvorbu bijelog masnog tkiva u tamno masno tkivo, kao i povećala smeđu masnu angiogenezu kod miševa.^[8]

Utvrđeno je da funkcionalne genetičke varijacije u FLT1 (rs9582036) utiču na preživljavanje karcinom pluća ne-malih ćelija.^[9]

Interakcije

Pokazano je da FLT1 stupa u interakcije sa PLCG1 ^[10] i VEGF-B.^[11][12]

Također pogledajte

• VEGF receptori