PDGFB

PDGFB
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1PDG, 3MJG, 4HQU, 4HQX, 4QCI
Identifikatori
Aliasi	PDGFB
Vanjski ID-jevi	OMIM: 190040 MGI: 97528 HomoloGene: 74303 GeneCards: PDGFB
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	39,244,982 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	80,014,977 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein homodimerization activity; • protein heterodimerization activity; • chemoattractant activity; • platelet-derived growth factor receptor binding; • platelet-derived growth factor binding; • superoxide-generating NADPH oxidase activator activity; • growth factor activity; • vezivanje identičnih proteina; • collagen binding; • GO:0001948, GO:0016582 vezivanje za proteine; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Ćelijska komponenta	• platelet alpha granule lumen; • citoplazma; • extracellular region; • Golđijeva membrana; • basolateral plasma membrane; • cell surface; • endoplasmic reticulum lumen; • membrana; • GO:0005578 Vanćelijski matriks; • Vanćelijsko; • Golgi lumen; • collagen-containing extracellular matrix;
Biološki proces	• activation of protein kinase B activity; • positive regulation of DNA biosynthetic process; • positive regulation of chemotaxis; • cellular response to growth factor stimulus; • positive regulation of protein tyrosine kinase activity; • peptidyl-tyrosine phosphorylation; • positive regulation of cell division; • development of the heart; • positive regulation of glomerular filtration; • positive regulation of mitotic nuclear division; • positive regulation of MAP kinase activity; • positive regulation of metanephric mesenchymal cell migration; • positive regulation of hyaluronan biosynthetic process; • MAPK cascade; • protein phosphorylation; • positive regulation of glomerular mesangial cell proliferation; • cellular response to mycophenolic acid; • positive regulation of fibroblast proliferation; • activation of protein kinase activity; • multicellular organism development; • positive regulation of protein autophosphorylation; • positive regulation of reactive oxygen species metabolic process; • reactive oxygen species metabolic process; • GO:0045996 negative regulation of transcription, DNA-templated; • protein kinase C signaling; • metanephric glomerular mesangial cell development; • negative regulation of phosphatidylinositol biosynthetic process; • response to wounding; • positive regulation of phosphatidylinositol 3-kinase activity; • cell chemotaxis; • positive regulation of ERK1 and ERK2 cascade; • platelet degranulation; • positive regulation of cell population proliferation; • positive regulation of DNA replication; • GO:1901313 positive regulation of gene expression; • embryonic placenta development; • paracrine signaling; • monocyte chemotaxis; • positive regulation of endothelial cell proliferation; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of calcium ion import; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0035404 peptidyl-serine phosphorylation; • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; • positive regulation of blood vessel endothelial cell migration; • Hematopoeza; • positive regulation of cell migration; • positive regulation of peptidyl-tyrosine phosphorylation; • extracellular matrix organization; • negative regulation of protein binding; • positive regulation of MAPK cascade; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of platelet activation; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of vascular associated smooth muscle cell migration; • positive chemotaxis; • negative regulation of vascular associated smooth muscle cell differentiation; • interleukin-18-mediated signaling pathway; • positive regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of gene expression; • positive regulation of smooth muscle cell migration; • positive regulation of smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell dedifferentiation; • platelet-derived growth factor receptor signaling pathway; • positive regulation of vascular associated smooth muscle cell proliferation; • negative regulation of platelet-derived growth factor receptor-beta signaling pathway; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	5155
	18591
	ENSG00000100311
	ENSMUSG00000000489
	P01127
	P31240
	NM_033016; NM_002608
	NM_011057
	NP_002599; NP_148937
	NP_035187
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica B trombocitno-izvedenog faktora rasta jest protein koji je kod ljudi kodiran genom PDGFB sa hromosoma 22.^[5]^[6]

Kratke činjenice Dostupne strukture, PDB ...

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[6]

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[3]

[4]

10	20	30	40	50
MNRCWALFLS	LCCYLRLVSA	EGDPIPEELY	EMLSDHSIRS	FDDLQRLLHG
DPGEEDGAEL	DLNMTRSHSG	GELESLARGR	RSLGSLTIAE	PAMIAECKTR
TEVFEISRRL	IDRTNANFLV	WPPCVEVQRC	SGCCNNRNVQ	CRPTQVQLRP
VQVRKIEIVR	KKPIFKKATV	TLEDHLACKC	ETVAAARPVT	RSPGGSQEQR
AKTPQTRVTI	RTVRVRRPPK	GKHRKFKHTH	DKTALKETLG	A

PDGFB

Aminokiselinska sekvenca

Funkcija

Klinički značaj

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Reference

Dopunska literatura

Vanjski linkovi

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