SCN4B

β-podjedinica 4 natrijevog kanala, znana i kao SCN4B ili Naβ4, i pomoćna je podjedinica natrijskih kanala koja može promijeniti njihovu kinetiku. To jest protein koji je kod ljudi kodiran genom SCN4B sa hromosoma 11.^[5][6] Mutacije u SCN4B povezane su sa sindromom dugog QT intervala.^[7]

SCN4B
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4MZ2, 4MZ3
Identifikatori
Aliasi	SCN4B
Vanjski ID-jevi	OMIM: 608256 MGI: 2687406 HomoloGene: 18384 GeneCards: SCN4B
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11q23.3 Početak 118,133,377 bp[1] Kraj 118,152,888 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9|9 A5.2 Početak 45,049,693 bp[2] Kraj 45,065,450 bp[2]
Ontologija gena Molekularna funkcija • sodium channel regulator activity • transmembrane transporter binding • sodium channel activity • voltage-gated ion channel activity • voltage-gated sodium channel activity involved in cardiac muscle cell action potential • voltage-gated sodium channel activity Ćelijska komponenta • voltage-gated sodium channel complex • integral component of membrane • membrana • Interkalirani disk • intrinsic component of plasma membrane • ćelijska membrana Biološki proces • cardiac muscle contraction • sodium ion transmembrane transport • sodium ion transport • regulation of ion transmembrane transport • cardiac muscle cell action potential involved in contraction • ion transport • regulation of sodium ion transmembrane transporter activity • GO:0061423 positive regulation of sodium ion transport • AV node cell action potential • regulation of heart rate by cardiac conduction • membrane depolarization during cardiac muscle cell action potential • regulation of ventricular cardiac muscle cell membrane repolarization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6330	399548
Ensembl	ENSG00000177098	ENSMUSG00000046480
UniProt	Q8IWT1	Q7M729
RefSeq (mRNK)	NM_001142348 NM_001142349 NM_174934	NM_001013390
RefSeq (bjelančevina)	NP_001135820 NP_001135821 NP_777594	NP_001013408
Lokacija (UCSC)	Chr 11: 118.13 – 118.15 Mb	Chr 9: 45.05 – 45.07 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 228 aminokiselina, a molekulska masa 24.969 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MPGAGDGGKA		PARWLGTGLL		GLFLLPVTLS		LEVSVGKATD		IYAVNGTEIL
LPCTFSSCFG		FEDLHFRWTY		NSSDAFKILI		EGTVKNEKSD		PKVTLKDDDR
ITLVGSTKEK		MNNISIVLRD		LEFSDTGKYT		CHVKNPKENN		LQHHATIFLQ
VVDRLEEVDN		TVTLIILAVV		GGVIGLLILI		LLIKKLIIFI		LKKTREKKKE
CLVSSSGNDN		TENGLPGSKA		EEKPPSKV

Funkcija

SCN4B might additionally function as a cell adhesion molecule.^[8][9]

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