SLITRK5

SLIT i NTRK-liki protein 5 je protein koji je kod ljudi kodiran genom SLITRK5.^[5][6][7]

SLITRK5
Identifikatori
Aliasi	SLITRK5
Vanjski ID-jevi	OMIM: 609680 MGI: 2679448 HomoloGene: 9193 GeneCards: SLITRK5
Lokacija gena (čovjek) Hrom. Hromosom 13 (čovjek)[1] Bend 13q31.2 Početak 87,671,371 bp[1] Kraj 87,696,272 bp[1]
Lokacija gena (miš) Hrom. Hromosom 14 (miš)[2] Bend 14|14 E4 Početak 111,912,529 bp[2] Kraj 111,920,573 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ortolozi
Vrste	Čovjek	Miš
Entrez	26050	75409
Ensembl	ENSG00000165300	ENSMUSG00000033214
UniProt	O94991	Q810B7
RefSeq (mRNK)	NM_015567 NM_001384609 NM_001384610	NM_029273 NM_198865 NM_001378768 NM_001378769 NM_001378770
RefSeq (bjelančevina)	NP_056382	NP_942565 NP_001365697 NP_001365698 NP_001365699
Lokacija (UCSC)	Chr 13: 87.67 – 87.7 Mb	Chr 14: 111.91 – 111.92 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 958 aminokiselina, a molekulska težina 107.486 Da.^[8].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin

P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MHTCCPPVTL		EQDLHRKMHS		WMLQTLAFAV		TSLVLSCAET		IDYYGEICDN
ACPCEEKDGI		LTVSCENRGI		ISLSEISPPR		FPIYHLLLSG		NLLNRLYPNE
FVNYTGASIL		HLGSNVIQDI		ETGAFHGLRG		LRRLHLNNNK		LELLRDDTFL
GLENLEYLQV		DYNYISVIEP		NAFGKLHLLQ		VLILNDNLLS		SLPNNLFRFV
PLTHLDLRGN		RLKLLPYVGL		LQHMDKVVEL		QLEENPWNCS		CELISLKDWL
DSISYSALVG		DVVCETPFRL		HGRDLDEVSK		QELCPRRLIS		DYEMRPQTPL
STTGYLHTTP		ASVNSVATSS		SAVYKPPLKP		PKGTRQPNKP		RVRPTSRQPS
KDLGYSNYGP		SIAYQTKSPV		PLECPTACSC		NLQISDLGLN		VNCQERKIES
IAELQPKPYN		PKKMYLTENY		IAVVRRTDFL		EATGLDLLHL		GNNRISMIQD
RAFGDLTNLR		RLYLNGNRIE		RLSPELFYGL		QSLQYLFLQY		NLIREIQSGT
FDPVPNLQLL		FLNNNLLQAM		PSGVFSGLTL		LRLNLRSNHF		TSLPVSGVLD
QLKSLIQIDL		HDNPWDCTCD		IVGMKLWVEQ		LKVGVLVDEV		ICKAPKKFAE
TDMRSIKSEL		LCPDYSDVVV		STPTPSSIQV		PARTSAVTPA		VRLNSTGAPA
SLGAGGGASS		VPLSVLILSL		LLVFIMSVFV		AAGLFVLVMK		RRKKNQSDHT
STNNSDVSSF		NMQYSVYGGG		GGTGGHPHAH		VHHRGPALPK		VKTPAGHVYE
YIPHPLGHMC		KNPIYRSREG		NSVEDYKDLH		ELKVTYSSNH		HLQQQQQPPP
PPQQPQQQPP		PQLQLQPGEE		ERRESHHLRS		PAYSVSTIEP		REDLLSPVQD
ADRFYRGILE		PDKHCSTTPA		GNSLPEYPKF		PCSPAAYTFS		PNYDLRRPHQ
YLHPGAGDSR		LREPVLYSPP		SAVFVEPNRN		EYLELKAKLN		VEPDYLEVLE
KQTTFSQF

Funkcija

Članovi porodice SLITRK, poput SLITRK5, integralni su membranski proteini s dva N-terminalna ponavljajuća domena (LRR) bogata leucinom, sličnea onima SLIT proteina (vidi SLIT1; MIM 603742). Većina SLITRK-ova, uključujući SLITRK5, također imaju C-terminalne regije koje dijele homologiju s receptorima za neurotropine (vidi NTRK1; MIM 191315). SLITRK se eksprimiraju pretežno u neuronskim tkivima i imaju aktivnost moduliranja neurita (Aruga et al., 2003). [Dobavljač OMIM] (Aruga et al., 2003).[supplied by OMIM]^[7]