TAL1

Protein 1 T-ćelijske akutne limfocistne leukemije (tj. TAL1, također zvana leukemija matičnih ćelija/akutna leukemija T-ćelija 1 (tj. SCL/TAL1]) jest protein koji je kod ljudi kodiran genom TAL1 sa hromosoma 1.^[5][6]

TAL1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2YPA, 2YPB
Identifikatori
Aliasi	TAL1
Vanjski ID-jevi	OMIM: 187040 MGI: 98480 HomoloGene: 2400 GeneCards: TAL1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p33 Početak 47,216,290 bp[1] Kraj 47,232,225 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4 D1|4 52.73 cM Početak 114,913,623 bp[2] Kraj 114,928,952 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • vezivanje sa DNK • RNA polymerase II transcription regulatory region sequence-specific DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • histone deacetylase binding • chromatin binding • GO:0000975 transcription cis-regulatory region binding • E-box binding • GO:0001948, GO:0016582 vezivanje za proteine • protein heterodimerization activity • vezivanje enzima • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • histone deacetylase complex • transcription regulator complex • Lsd1/2 complex • jedro • nukleoplazma • GO:0009327 makromolekulani kompleks Biološki proces • megakaryocyte development • megakaryocyte differentiation • myeloid cell differentiation • cell fate commitment • Ćelijska diferencijacija • GO:0009373 regulation of transcription, DNA-templated • regulation of mast cell differentiation • spinal cord association neuron differentiation • positive regulation of protein-containing complex assembly • locomotory behavior • positive regulation of erythrocyte differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • regulation of stem cell population maintenance • platelet formation • positive regulation of mitotic cell cycle • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • generation of neurons • basophil differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • multicellular organism development • regulation of cell population proliferation • hematopoietic stem cell differentiation • astrocyte fate commitment • Angiogeneza • neuron differentiation • embryonic hemopoiesis • erythrocyte differentiation • definitive hemopoiesis • regulation of myeloid cell differentiation • positive regulation of cell division • hemangioblast cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • erythrocyte maturation • regulation of hematopoietic stem cell differentiation • Hematopoeza • transcription by RNA polymerase II • negative regulation of erythrocyte differentiation • positive regulation of protein tyrosine kinase activity • positive regulation of signaling receptor activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6886	21349
Ensembl	ENSG00000162367	ENSMUSG00000028717
UniProt	P17542	P22091
RefSeq (mRNK)	NM_001287347 NM_001290403 NM_001290404 NM_001290405 NM_001290406 NM_003189	NM_011527 NM_001287388
RefSeq (bjelančevina)	NP_001274276 NP_001277332 NP_001277333 NP_001277334 NP_001277335 NP_003180	NP_001274317 NP_035657
Lokacija (UCSC)	Chr 1: 47.22 – 47.23 Mb	Chr 4: 114.91 – 114.93 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 331 aminokiselina, a molekulska težina 34.271 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MTERPPSEAA		RSDPQLEGRD		AAEASMAPPH		LVLLNGVAKE		TSRAAAAEPP
VIELGARGGP		GGGPAGGGGA		ARDLKGRDAA		TAEARHRVPT		TELCRPPGPA
PAPAPASVTA		ELPGDGRMVQ		LSPPALAAPA		APGRALLYSL		SQPLASLGSG
FFGEPDAFPM		FTTNNRVKRR		PSPYEMEITD		GPHTKVVRRI		FTNSRERWRQ
QNVNGAFAEL		RKLIPTHPPD		KKLSKNEILR		LAMKYINFLA		KLLNDQEEEG
TQRAKTGKDP		VVGAGGGGGG		GGGGAPPDDL		LQDVLSPNSS		CGSSLDGAAS
PDSYTEEPAP		KHTARSLHPA		MLPAADGAGP		R

Funkcija

Protein koji kodira TAL1 je transkripcijski faktor zvani bazni heliks-petkja-heliks.

Interakcije

Pokazalo se da je TAL1 u interakcijama sa:

• CBFA2T3,^[8]
• EP300,^[9]
• GATA1,^[8][10]
• LDB1,^[8]
• LMO1,^[11][12]
• LMO2,^{[8][10][11][12]}
• SIN3A,^[13]
• SP1TF,^[14] i
• TCF3.^[8][15]