TGFBR1

TGFBR1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1B6C, 1IAS, 1PY5, 1RW8, 1VJY, 2L5S, 2PJY, 2WOT, 2WOU, 2X7O, 3FAA, 3GXL, 3HMM, 3KCF, 3KFD, 3TZM, 4X0M, 4X2J, 4X2K, 4X2N, 4X2G, 4X2F, 5E8W, 5E8X, 5E8U, 5E8T, 5E8S, 5E90, 5E8Z
Identifikatori
Aliasi	TGFBR1
Vanjski ID-jevi	OMIM: 190181 MGI: 98728 HomoloGene: 3177 GeneCards: TGFBR1
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	99,154,192 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	47,414,931 bp
Ontologija gena
Molekularna funkcija	• type II transforming growth factor beta receptor binding; • I-SMAD binding; • transforming growth factor beta-activated receptor activity; • kinase activity; • signaling receptor binding; • ATP binding; • protein kinase activity; • vezivanje iona metala; • protein serine/threonine kinase activity; • transforming growth factor beta receptor activity, type I; • aktivnost sa transferazom; • growth factor binding; • transmembrane receptor protein serine/threonine kinase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • SMAD binding; • nucleotide binding; • transforming growth factor beta binding; • activin binding;
Ćelijska komponenta	• endozom; • membrana; • bicellular tight junction; • cell surface; • Lipidni splav; • integral component of membrane; • receptor complex; • ćelijska membrana; • međućelijske veze; • intracellular anatomical structure; • intracellular membrane-bounded organelle; • integral component of plasma membrane; • activin receptor complex; • jedro;
Biološki proces	• skeletal system development; • response to cholesterol; • regulation of protein ubiquitination; • post-embryonic development; • protein phosphorylation; • negative regulation of chondrocyte differentiation; • mesenchymal cell differentiation; • Angiogeneza; • transforming growth factor beta receptor signaling pathway; • positive regulation of filopodium assembly; • extracellular structure organization; • pharyngeal system development; • GO:0097285 apoptoza; • cellular response to transforming growth factor beta stimulus; • pathway-restricted SMAD protein phosphorylation; • positive regulation of protein kinase B signaling; • GO:0009373 regulation of transcription, DNA-templated; • Nefrogeneza; • collagen fibril organization; • thymus development; • cell motility; • negative regulation of extrinsic apoptotic signaling pathway; • positive regulation of apoptotic signaling pathway; • in utero embryonic development; • negative regulation of transforming growth factor beta receptor signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • heart development; • positive regulation of cell growth; • parathyroid gland development; • artery morphogenesis; • blastocyst development; • activin receptor signaling pathway; • roof of mouth development; • Ćelijska diferencijacija; • male gonad development; • Fosforilacija; • skeletal system morphogenesis; • Zarastanje rana; • negative regulation of apoptotic process; • epithelial to mesenchymal transition; • Regulacija ekspresije gena; • embryonic cranial skeleton morphogenesis; • peptidyl-threonine phosphorylation; • GO:0007243 intracellular signal transduction; • positive regulation of endothelial cell proliferation; • positive regulation of cell migration; • regulation of epithelial to mesenchymal transition; • positive regulation of pathway-restricted SMAD protein phosphorylation; • endothelial cell activation; • negative regulation of endothelial cell proliferation; • transmembrane receptor protein serine/threonine kinase signaling pathway; • lens development in camera-type eye; • GO:0035404 peptidyl-serine phosphorylation; • positive regulation of cell population proliferation; • regulation of growth; • neuron fate commitment; • regulation of protein binding; • endothelial cell migration; • germ cell migration; • positive regulation of SMAD protein signal transduction; • cardiac epithelial to mesenchymal transition; • GO:0072468 Transdukcija signala; • anterior/posterior pattern specification; • proepicardium development; • ventricular trabecula myocardium morphogenesis; • ventricular compact myocardium morphogenesis; • positive regulation of epithelial to mesenchymal transition; • protein deubiquitination; • positive regulation of stress fiber assembly; • regulation of cardiac muscle cell proliferation; • ventricular septum morphogenesis; • angiogenesis involved in coronary vascular morphogenesis; • coronary artery morphogenesis; • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; • positive regulation of tight junction disassembly; • epicardium morphogenesis; • positive regulation of apoptotic process; • GO:1901313 positive regulation of gene expression; • pattern specification process;
	Izvori:Amigo / QuickGO
Ortolozi
	7046
	21812
	ENSG00000106799
	ENSMUSG00000007613
	P36897
	Q64729
	NM_001130916; NM_001306210; NM_004612
	NM_009370; NM_001312868; NM_001312869
	NP_001124388; NP_001293139; NP_004603
	NP_001299797; NP_001299798; NP_033396
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Beta receptor I transformirajućeg faktora rasta (aktivinski receptor A tipa sličnog kunazi II, 53kDa) je membranski vezani TGF-beta receptorski protein porodice receptora TGF-beta za superporodicu signalnih liganda TGF-beta. TGFBR1 je njegov ljudski gen.

Kratke činjenice Dostupne strukture, PDB ...

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MEAAVAAPRP	RLLLLVLAAA	AAAAAALLPG	ATALQCFCHL	CTKDNFTCVT
DGLCFVSVTE	TTDKVIHNSM	CIAEIDLIPR	DRPFVCAPSS	KTGSVTTTYC
CNQDHCNKIE	LPTTVKSSPG	LGPVELAAVI	AGPVCFVCIS	LMLMVYICHN
RTVIHHRVPN	EEDPSLDRPF	ISEGTTLKDL	IYDMTTSGSG	SGLPLLVQRT
IARTIVLQES	IGKGRFGEVW	RGKWRGEEVA	VKIFSSREER	SWFREAEIYQ
TVMLRHENIL	GFIAADNKDN	GTWTQLWLVS	DYHEHGSLFD	YLNRYTVTVE
GMIKLALSTA	SGLAHLHMEI	VGTQGKPAIA	HRDLKSKNIL	VKKNGTCCIA
DLGLAVRHDS	ATDTIDIAPN	HRVGTKRYMA	PEVLDDSINM	KHFESFKRAD
IYAMGLVFWE	IARRCSIGGI	HEDYQLPYYD	LVPSDPSVEE	MRKVVCEQKL
RPNIPNRWQS	CEALRVMAKI	MRECWYANGA	ARLTALRIKK	TLSQLSQQEG
IKM

TGFBR1

Aminokiselinska sekvenca

Funkcija

Interakcije

Inhibitori

Studije na životinjama

Reference

Dopunska literatura

Vanjski linkovi

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