TSC1

TSC1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	5EJC, 4Z6Y
Identifikatori
Aliasi	TSC1
Vanjski ID-jevi	OMIM: 605284 MGI: 1929183 HomoloGene: 314 GeneCards: TSC1
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	132,946,874 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	28,581,179 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• chaperone binding; • GO:0001948, GO:0016582 vezivanje za proteine; • protein N-terminus binding; • Hsp70 protein binding; • ATPase inhibitor activity; • Hsp90 protein binding; • GTPase activating protein binding;
Ćelijska komponenta	• citoplazma; • cell cortex; • growth cone; • intracellular membrane-bounded organelle; • lamellipodium; • membrana; • Mikronit; • TSC1-TSC2 complex; • citoskelet; • citosol; • jedro; • perinuklearno područje citoplazme; • Lipidna kapljica; • ćelijska membrana; • projekcija ćelije; • GO:0009327 makromolekulani kompleks; • chaperone complex; • GO:0097483, GO:0097481 postsynaptic density;
Biološki proces	• rRNA export from nucleus; • regulation of cell cycle; • neural tube closure; • cerebral cortex development; • memory T cell differentiation; • regulation of protein kinase activity; • positive regulation of focal adhesion assembly; • myelination; • GO:1903105 negative regulation of insulin receptor signaling pathway; • synapse organization; • regulation of translation; • hippocampus development; • regulation of phosphoprotein phosphatase activity; • cell-matrix adhesion; • potassium ion transport; • adaptive immune response; • protein heterooligomerization; • Nefrogeneza; • nervous system development; • cell projection organization; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • regulation of focal adhesion assembly; • glucose import; • regulation of cell-matrix adhesion; • negative regulation of cell size; • response to insulin; • cardiac muscle cell differentiation; • negative regulation of translation; • negative regulation of cell population proliferation; • cellular response to oxygen-glucose deprivation; • adult locomotory behavior; • negative regulation of TOR signaling; • regulation of neuron death; • negative regulation of macroautophagy; • negative regulation of neuron projection development; • positive regulation of macroautophagy; • GO:0034259 negative regulation of GTPase activity; • regulation of stress fiber assembly; • positive regulation of stress fiber assembly; • negative regulation of oxidative stress-induced neuron death; • negative regulation of ATP-dependent activity; • protein stabilization;
	Izvori:Amigo / QuickGO
Ortolozi
	7248
	64930
	ENSG00000165699
	ENSMUSG00000026812
	Q92574
	Q9EP53
	NM_000368; NM_001008567; NM_001162426; NM_001162427; NM_001362177
	NM_022887; NM_001289575; NM_001289576
	NP_000359; NP_001155898; NP_001155899; NP_001349106
	NP_001276504; NP_001276505; NP_075025
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 1 gomoljaste skleroze (TSC1), poznat i kao hamartin, je protein koji je kod ljudi kodiran genom TSC1.^[5]

Kratke činjenice Dostupne strukture, PDB ...

[5]

[1]

[2]

[3]

[4]

10	20	30	40	50
MAQQANVGEL	LAMLDSPMLG	VRDDVTAVFK	ENLNSDRGPM	LVNTLVDYYL
ETSSQPALHI	LTTLQEPHDK	HLLDRINEYV	GKAATRLSIL	SLLGHVIRLQ
PSWKHKLSQA	PLLPSLLKCL	KMDTDVVVLT	TGVLVLITML	PMIPQSGKQH
LLDFFDIFGR	LSSWCLKKPG	HVAEVYLVHL	HASVYALFHR	LYGMYPCNFV
SFLRSHYSMK	ENLETFEEVV	KPMMEHVRIH	PELVTGSKDH	ELDPRRWKRL
ETHDVVIECA	KISLDPTEAS	YEDGYSVSHQ	ISARFPHRSA	DVTTSPYADT
QNSYGCATST	PYSTSRLMLL	NMPGQLPQTL	SSPSTRLITE	PPQATLWSPS
MVCGMTTPPT	SPGNVPPDLS	HPYSKVFGTT	AGGKGTPLGT	PATSPPPAPL
CHSDDYVHIS	LPQATVTPPR	KEERMDSARP	CLHRQHHLLN	DRGSEEPPGS
KGSVTLSDLP	GFLGDLASEE	DSIEKDKEEA	AISRELSEIT	TAEAEPVVPR
GGFDSPFYRD	SLPGSQRKTH	SAASSSQGAS	VNPEPLHSSL	DKLGPDTPKQ
AFTPIDLPCG	SADESPAGDR	ECQTSLETSI	FTPSPCKIPP	PTRVGFGSGQ
PPPYDHLFEV	ALPKTAHHFV	IRKTEELLKK	AKGNTEEDGV	PSTSPMEVLD
RLIQQGADAH	SKELNKLPLP	SKSVDWTHFG	GSPPSDEIRT	LRDQLLLLHN
QLLYERFKRQ	QHALRNRRLL	RKVIKAAALE	EHNAAMKDQL	KLQEKDIQMW
KVSLQKEQAR	YNQLQEQRDT	MVTKLHSQIR	QLQHDREEFY	NQSQELQTKL
EDCRNMIAEL	RIELKKANNK	VCHTELLLSQ	VSQKLSNSES	VQQQMEFLNR
QLLVLGEVNE	LYLEQLQNKH	SDTTKEVEMM	KAAYRKELEK	NRSHVLQQTQ
RLDTSQKRIL	ELESHLAKKD	HLLLEQKKYL	EDVKLQARGQ	LQAAESRYEA
QKRITQVFEL	EILDLYGRLE	KDGLLKKLEE	EKAEAAEAAE	ERLDCCNDGC
SDSMVGHNEE	ASGHNGETKT	PRPSSARGSS	GSRGGGGSSS	SSSELSTPEK
PPHQRAGPFS	SRWETTMGEA	SASIPTTVGS	LPSSKSFLGM	KARELFRNKS
ESQCDEDGMT	SSLSESLKTE	LGKDLGVEAK	IPLNLDGPHP	SPPTPDSVGQ
LHIMDYNETH	HEHS

TSC1

Aminokiselinska sekvenca

Funkcija

Klinički značaj

Interakcije

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Reference

Dopunska literatura

Vanjski linkovi

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