COP9 constitutive photomorphogenic homolog subunit 5

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.^[5]

COPS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D10, 4D18, 4F7O, 4WSN
Identifiers
Aliases	COPS5, CSN5, JAB1, MOV-34, SGN5, COP9 constitutive photomorphogenic homolog subunit 5, COP9 signalosome subunit 5
External IDs	OMIM: 604850; MGI: 1349415; HomoloGene: 55992; GeneCards: COPS5; OMA:COPS5 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.1 Start 67,043,079 bp[1] End 67,083,783 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 A2|1 2.29 cM Start 10,094,826 bp[2] End 10,108,393 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right ventricle myocardium of left ventricle gastrocnemius muscle biceps brachii vastus lateralis muscle Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii right testis left testis Top expressed in genital tubercle tail of embryo medial ganglionic eminence facial motor nucleus temporal muscle ventricular zone lens muscle of thigh triceps brachii muscle seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity transcription coactivator activity metal ion binding peptidase activity protein binding thiol-dependent deubiquitinase hydrolase activity metallopeptidase activity NEDD8-specific protease activity enzyme binding macrophage migration inhibitory factor binding metalloendopeptidase activity Cellular component cytoplasm eukaryotic translation initiation factor 3 complex synaptic vesicle synapse nucleoplasm cell junction perinuclear region of cytoplasm COP9 signalosome cytoplasmic vesicle nucleus chromatin cytosol Biological process protein biosynthesis nucleotide-excision repair, DNA damage recognition transcription by RNA polymerase II proteolysis regulation of cell cycle protein deubiquitination regulation of JNK cascade exosomal secretion transcription-coupled nucleotide-excision repair regulation of IRE1-mediated unfolded protein response positive regulation of transcription by RNA polymerase II translational initiation protein deneddylation post-translational protein modification negative regulation of apoptotic process positive regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10987 26754 Ensembl ENSG00000121022 ENSMUSG00000025917 UniProt Q92905 O35864 RefSeq (mRNA) NM_006837 NM_001277101 NM_013715 RefSeq (protein) NP_006828 NP_006828.2 NP_001264030 NP_038743 Location (UCSC) Chr 8: 67.04 – 67.08 Mb Chr 1: 10.09 – 10.11 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27^Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.^[5]

Interactions

COP9 constitutive photomorphogenic homolog subunit 5 has been shown to interact with Macrophage migration inhibitory factor,^[6][7] GFER,^[8] BCL3,^[9] Ubiquitin carboxy-terminal hydrolase L1,^[10] S100A7^[11] and C-jun.^[12]

See also

• COPS1
• COPS2
• COPS3
• COPS4
• COPS6
• COPS7A
• COPS7B
• COPS8