Panteteinaza jest enzim koji je kod ljudi kodiran genom VNN1.[5][6]
Kratke činjenice Dostupne strukture, PDB ...
Zatvori
Dužina polipeptidnog lanca je 513 aminokiselina, а molekulska težina 57.012 Da.[7]
10 | | 20 | | 30 | | 40 | | 50 |
MTTQLPAYVA | | ILLFYVSRAS | | CQDTFTAAVY | | EHAAILPNAT | | LTPVSREEAL |
ALMNRNLDIL | | EGAITSAADQ | | GAHIIVTPED | | AIYGWNFNRD | | SLYPYLEDIP |
DPEVNWIPCN | | NRNRFGQTPV | | QERLSCLAKN | | NSIYVVANIG | | DKKPCDTSDP |
QCPPDGRYQY | | NTDVVFDSQG | | KLVARYHKQN | | LFMGENQFNV | | PKEPEIVTFN |
TTFGSFGIFT | | CFDILFHDPA | | VTLVKDFHVD | | TIVFPTAWMN | | VLPHLSAVEF |
HSAWAMGMRV | | NFLASNIHYP | | SKKMTGSGIY | | APNSSRAFHY | | DMKTEEGKLL |
LSQLDSHPSH | | SAVVNWTSYA | | SSIEALSSGN | | KEFKGTVFFD | | EFTFVKLTGV |
AGNYTVCQKD | | LCCHLSYKMS | | ENIPNEVYAL | | GAFDGLHTVE | | GRYYLQICTL |
LKCKTTNLNT | | CGDSAETAST | | RFEMFSLSGT | | FGTQYVFPEV | | LLSENQLAPG |
EFQVSTDGRL | | FSLKPTSGPV | | LTVTLFGRLY | | EKDWASNASS | | GLTAQARIIM |
LIVIAPIVCS | | LSW |
Ovaj genski proizvod je član vaninske porodice proteina koji međusobno dijele veliku sličnost sekvenci, kao i sa biotinidazom. Porodica uključuje izlučene i membranom povezane proteine, od kojih je nekoliko prijavljeno da učestvuju u prometu hematopoetskih ćelija. Nijedna biotinidazna aktivnost nije dokazana ni za jedan od vaninski proteina; međutim, oni posjeduju panteteinaznu aktivnost, koja može imati ulogu u odgovoru na oksidativni stres. Ovaj protein, kao i njegov mišji homolog, vjerovatno je GPI usidrena molekula ćelijske površine. Mišji protein eksprimiraju perivaskularne timusne stromske ćelije i reguliraju migraciju progenitornih T-ćelija u timus. Ovaj gen je u neposrednoj blizini i u istoj transkripcijskoj orijentaciji kao i dva druga gena vanina na hromosomu 6q, regija 23-q24.[6]
Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.
- Aurrand-Lions M, Galland F, Bazin H, et al. (1997). "Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing". Immunity. 5 (5): 391–405. doi:10.1016/S1074-7613(00)80496-3. PMID 8934567.
- Maras B, Barra D, Duprè S, Pitari G (1999). "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?". FEBS Lett. 461 (3): 149–52. doi:10.1016/S0014-5793(99)01439-8. PMID 10567687. S2CID 25738323.
- Martin F, Malergue F, Pitari G, et al. (2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533. S2CID 10763223.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kristiansen TZ, Bunkenborg J, Gronborg M, et al. (2005). "A proteomic analysis of human bile". Mol. Cell. Proteomics. 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Min-Oo G, Fortin A, Pitari G, et al. (2007). "Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus". J. Exp. Med. 204 (3): 511–24. doi:10.1084/jem.20061252. PMC 2137903. PMID 17312006.