AASDH

Aminoadipat-semialdehid-dehidrogenaza jest protein/enzim koji je kod ljudi kodiran genom AASDH sa hromosoma 4.^[5]

AASDH
Identifikatori
Aliasi	AASDH
Vanjski ID-jevi	OMIM: 614365 MGI: 2442517 HomoloGene: 71711 GeneCards: AASDH
EC broj	1.2.1.31
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4q12 Početak 56,338,287 bp[1] Kraj 56,387,508 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5|5 C3.3 Početak 77,021,506 bp[2] Kraj 77,053,361 bp[2]
Ortolozi
Vrste	Čovjek	Miš
Entrez	132949	231326
Ensembl	ENSG00000157426	ENSMUSG00000055923
UniProt	Q4L235	Q80WC9
RefSeq (mRNK)	NM_001286668 NM_001286669 NM_001286670 NM_001286671 NM_001286672 NM_181806 NM_001323890 NM_001323892 NM_001323893 NM_001323899	NM_173765 NM_001377004
RefSeq (bjelančevina)	NP_001273597 NP_001273598 NP_001273599 NP_001273600 NP_001273601 NP_001310819 NP_001310821 NP_001310822 NP_001310828 NP_861522	NP_776126 NP_001363933
Lokacija (UCSC)	Chr 4: 56.34 – 56.39 Mb	Chr 5: 77.02 – 77.05 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.098 aminokiselina, а molekulska težina 122.597 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MTLQELVHKA		ASCYMDRVAV		CFDECNNQLP		VYYTYKTVVN		AASELSNFLL
LHCDFQGIRE		IGLYCQPGID		LPSWILGILQ		VPAAYVPIEP		DSPPSLSTHF
MKKCNLKYIL		VEKKQINKFK		SFHETLLNYD		TFTVEHNDLV		LFRLHWKNTE
VNLMLNDGKE		KYEKEKIKSI		SSEHVNEEKA		EEHMDLRLKH		CLAYVLHTSG
TTGIPKIVRV		PHKCIVPNIQ		HFRVLFDITQ		EDVLFLASPL		TFDPSVVEIF
LALSSGASLL		IVPTSVKLLP		SKLASVLFSH		HRVTVLQATP		TLLRRFGSQL
IKSTVLSATT		SLRVLALGGE		AFPSLTVLRS		WRGEGNKTQI		FNVYGITEVS
SWATIYRIPE		KTLNSTLKCE		LPVQLGFPLL		GTVVEVRDTN		GFTIQEGSGQ
VFLGGRNRVC		FLDDEVTVPL		GTMRATGDFV		TVKDGEIFFL		GRKDSQIKRH
GKRLNIELVQ		QVAEELQQVE		SCAVTWYNQE		KLILFMVSKD		ASVKEYIFKE
LQKYLPSHAV		PDELVLIDSL		PFTSHGKIDV		SELNKIYLNY		INLKSENKLS
GKEDLWEKLQ		YLWKSTLNLP		EDLLRVPDES		LFLNSGGDSL		KSIRLLSEIE
KLVGTSVPGL		LEIILSSSIL		EIYNHILQTV		VPDEDVTFRK		SCATKRKLSD
INQEEASGTS		LHQKAIMTFT		CHNEINAFVV		LSRGSQILSL		NSTRFLTKLG
HCSSACPSDS		VSQTNIQNLK		GLNSPVLIGK		SKDPSCVAKV		SEEGKPAIGT
QKMELHVRWR		SDTGKCVDAS		PLVVIPTFDK		SSTTVYIGSH		SHRMKAVDFY
SGKVKWEQIL		GDRIESSACV		SKCGNFIVVG		CYNGLVYVLK		SNSGEKYWMF
TTEDAVKSSA		TMDPTTGLIY		IGSHDQHAYA		LDIYRKKCVW		KSKCGGTVFS
SPCLNLIPHH		LYFATLGGLL		LAVNPATGNV		IWKHSCGKPL		FSSPQCCSQY
ICIGCVDGNL		LCFTHFGEQV		WQFSTSGPIF		SSPCTSPSEQ		KIFFGSHDCF
IYCCNMKGHL		QWKFETTSRV		YATPFAFHNY		NGSNEMLLAA		ASTDGKVWIL
ESQSGQLQSV		YELPGEVFSS		PVVLESMLII		GCRDNYVYCL		DLLGGNQK

Funkcija

Ovaj gen kodira člana porodice enzima neribosomsko peptidnih sintetaza (NRPS). Kodirani protein sadrži domen koji veže AMP, domen koji se veže za PP (fosfopantetein ili pantetein 4'fosfat) i domen za vezivanje pirolo-kinolin kinona (PQQ). Protein je eksprimiran u nekoliko tkiva odraslih.