PTGS2

PTGS2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR
Identifikatori
Aliasi	PTGS2
Vanjski ID-jevi	OMIM: 600262 MGI: 97798 HomoloGene: 31000 GeneCards: PTGS2
EC broj	1.14.99.1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	186,680,922 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	149,983,978 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• arachidonate 15-lipoxygenase activity; • vezivanje iona metala; • heme binding; • vezivanje enzima; • oxidoreductase activity; • protein homodimerization activity; • dioxygenase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • peroxidase activity; • prostaglandin-endoperoxide synthase activity; • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; • aktivnost sa transferazom;
Ćelijska komponenta	• citoplazma; • endoplasmic reticulum lumen; • membrana; • Kaveole; • neuron projection; • organelle membrane; • Endoplazmatski retikulum; • intracellular membrane-bounded organelle; • endoplasmic reticulum membrane; • GO:0009327 makromolekulani kompleks;
Biološki proces	• response to fructose; • Učenje; • response to organic substance; • lipoxygenase pathway; • cellular response to mechanical stimulus; • response to manganese ion; • Angiogeneza; • cellular response to hypoxia; • embryo implantation; • negative regulation of cell population proliferation; • response to cytokine; • negative regulation of smooth muscle contraction; • Memorija; • GO:0001306 response to oxidative stress; • maintenance of blood-brain barrier; • response to lithium ion; • response to tumor necrosis factor; • fatty acid biosynthetic process; • positive regulation of synaptic transmission, glutamatergic; • positive regulation of vasoconstriction; • response to organonitrogen compound; • inflammatory response; • positive regulation of smooth muscle contraction; • bone mineralization; • response to fatty acid; • response to vitamin D; • cellular response to UV; • positive regulation of fever generation; • cellular response to fluid shear stress; • positive regulation of synaptic plasticity; • regulation of blood pressure; • response to lipopolysaccharide; • positive regulation of platelet-derived growth factor production; • regulation of inflammatory response; • brown fat cell differentiation; • Nocicepcija; • response to radiation; • prostaglandin biosynthetic process; • cellular response to ATP; • Ovulacija; • positive regulation of smooth muscle cell proliferation; • hair cycle; • response to estradiol; • positive regulation of cell death; • positive regulation of cell migration involved in sprouting angiogenesis; • GO:1904578 response to organic cyclic compound; • lipid metabolism; • positive regulation of nitric oxide biosynthetic process; • response to glucocorticoid; • cyclooxygenase pathway; • fatty acid metabolic process; • positive regulation of fibroblast growth factor production; • decidualization; • regulation of cell population proliferation; • positive regulation of cell population proliferation; • negative regulation of calcium ion transport; • positive regulation of apoptotic process; • positive regulation of transforming growth factor beta production; • positive regulation of vascular endothelial growth factor production; • positive regulation of brown fat cell differentiation; • negative regulation of synaptic transmission, dopaminergic; • cellular oxidant detoxification; • GO:0010260 starenje; • NAD biosynthesis via nicotinamide riboside salvage pathway; • cellular response to heat; • positive regulation of prostaglandin biosynthetic process; • positive regulation of peptidyl-serine phosphorylation; • negative regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cellular response to non-ionic osmotic stress; • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; • cellular response to lead ion; • response to angiotensin; • prostaglandin metabolic process; • positive regulation of protein import into nucleus; • cytokine-mediated signaling pathway; • long-chain fatty acid biosynthetic process; • negative regulation of cell cycle; • regulation of neuroinflammatory response;
	Izvori:Amigo / QuickGO
Ortolozi
	5743
	19225
	ENSG00000073756
	ENSMUSG00000032487
	P35354
	Q05769
	NM_000963
	NM_011198
	NP_000954
	NP_035328
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Prostaglandin-endoperoksid sintaza 2 (prostaglandin sintaza G/H i ciklooksigenaza) (HUGO-ovi simboli PTGS2; HGNC ID, HGNC:9605), znana i kao ciklooksigenaza-2 ili COX-2, jest enzim koji je kod ljudi kodiran genom PTGS2 sa hromosoma 1^[5] Kod ljudi je to jedna od dviju ciklooksigenaza. Učestvuje u konverziji arahidonske kiseline u prostaglandin H2, važnog prekursora prostaciklina, koji se ispoljava u u upalama.

Kratke činjenice Dostupne strukture, PDB ...

[5]

[1]

[2]

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[4]

10	20	30	40	50
MLARALLLCA	VLALSHTANP	CCSHPCQNRG	VCMSVGFDQY	KCDCTRTGFY
GENCSTPEFL	TRIKLFLKPT	PNTVHYILTH	FKGFWNVVNN	IPFLRNAIMS
YVLTSRSHLI	DSPPTYNADY	GYKSWEAFSN	LSYYTRALPP	VPDDCPTPLG
VKGKKQLPDS	NEIVEKLLLR	RKFIPDPQGS	NMMFAFFAQH	FTHQFFKTDH
KRGPAFTNGL	GHGVDLNHIY	GETLARQRKL	RLFKDGKMKY	QIIDGEMYPP
TVKDTQAEMI	YPPQVPEHLR	FAVGQEVFGL	VPGLMMYATI	WLREHNRVCD
VLKQEHPEWG	DEQLFQTSRL	ILIGETIKIV	IEDYVQHLSG	YHFKLKFDPE
LLFNKQFQYQ	NRIAAEFNTL	YHWHPLLPDT	FQIHDQKYNY	QQFIYNNSIL
LEHGITQFVE	SFTRQIAGRV	AGGRNVPPAV	QKVSQASIDQ	SRQMKYQSFN
EYRKRFMLKP	YESFEELTGE	KEMSAELEAL	YGDIDAVELY	PALLVEKPRP
DAIFGETMVE	VGAPFSLKGL	MGNVICSPAY	WKPSTFGGEV	GFQIINTASI
QSLICNNVKG	CPFTSFSVPD	PELIKTVTIN	ASSSRSGLDD	INPTVLLKER
STEL

PTGS2

Aminokiselinska sekvenca

Struktura

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Reference

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