MBNL2

Sljepomišićnoliki protein 2 ili protein 2 sličan slijepom mišiću je protein koji je kod ljudi kodiran genom MBNL2, sa hromosoma13, sekvenca 13q32.1.^[5][6]

MBNL2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2E5S, 2RPP
Identifikatori
Aliasi	MBNL2
Vanjski ID-jevi	OMIM: 607327 MGI: 2145597 HomoloGene: 76766 GeneCards: MBNL2
Lokacija gena (čovjek) Hrom. Hromosom 13 (čovjek)[1] Bend 13q32.1 Početak 97,221,434 bp[1] Kraj 97,394,120 bp[1]
Lokacija gena (miš) Hrom. Hromosom 14 (miš)[2] Bend 14|14 E4 Početak 120,513,081 bp[2] Kraj 120,669,109 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje iona metala • vezivanje sa RNK Ćelijska komponenta • citoplazma • jedro • nukleoplazma Biološki proces • regulation of RNA splicing • mRNA processing • regulation of alternative mRNA splicing, via spliceosome • Prerada RNK Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10150	105559
Ensembl	ENSG00000139793	ENSMUSG00000022139
UniProt	Q5VZF2	Q8C181
RefSeq (mRNK)	NM_001306070 NM_144778 NM_207304	NM_175341 NM_207515 NM_001360376 NM_001360377 NM_001360378 NM_001360379 NM_001360380
RefSeq (bjelančevina)	NP_001292999 NP_659002 NP_997187 NP_001369578 NP_001369579 NP_001369580 NP_001369581 NP_001369582 NP_001369583 NP_001369585 NP_001369589 NP_001369590 NP_001369592 NP_001369595 NP_001369596 NP_001369597 NP_001369598 NP_001369599 NP_001369600 NP_001369601 NP_001369602 NP_001369603 NP_001369604 NP_001369605 NP_001369606 NP_001369607 NP_001369608 NP_001369609 NP_001369610 NP_001369611 NP_001369612 NP_001369613 NP_001369614 NP_001369615 NP_001369616 NP_001369617 NP_001369618 NP_001369619 NP_001369620 NP_001369621 NP_001369622 NP_001369623 NP_001369624 NP_001369625 NP_001369626	NP_780550 NP_997398 NP_001347305 NP_001347306 NP_001347307 NP_001347308 NP_001347309
Lokacija (UCSC)	Chr 13: 97.22 – 97.39 Mb	Chr 14: 120.51 – 120.67 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira protein cinkovog prsta tipa C3H, koji je sličan proteinu slijepog mišića Drosophila melanogaster. Kod Drosophila gen je potreban za diferencijaciju fotoreceptora. Opisano je nekoliko alternativno prerađenih varijanti transkripta, ali su samo neke sa određenom punom dužinom.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 373 aminokiseline, a molekulska težina 40.518 Da.^[7]

10		20		30		40		50
MALNVAPVRD		TKWLTLEVCR		QFQRGTCSRS		DEECKFAHPP		KSCQVENGRV
IACFDSLKGR		CSRENCKYLH		PPTHLKTQLE		INGRNNLIQQ		KTAAAMLAQQ
MQFMFPGTPL		HPVPTFPVGP		AIGTNTAISF		APYLAPVTPG		VGLVPTEILP
TTPVIVPGSP		PVTVPGSTAT		QKLLRTDKLE		VCREFQRGNC		ARGETDCRFA
HPADSTMIDT		SDNTVTVCMD		YIKGRCMREK		CKYFHPPAHL		QAKIKAAQHQ
ANQAAVAAQA		AAAAATVMAF		PPGALHPLPK		RQALEKSNGT		SAVFNPSVLH
YQQALTSAQL		QQHAAFIPTG		SVLCMTPATS		IDNSEIISRN		GMECQESALR
ITKHCYCTYY		PVSSSIELPQ		TAC

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin