MIER1

Protein 1 sa ranom indukcijom mezoderma jest protein koji je kod ljudi kodiran genom MIER1 sa hromosoma 1.^[5][6][7]

MIER1
Identifikatori
Aliasi	MIER1
Vanjski ID-jevi	OMIM: 616848 MGI: 1918398 HomoloGene: 136176 GeneCards: MIER1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p31.3 Početak 66,924,895 bp[1] Kraj 66,988,619 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4|4 C6 Početak 102,971,587 bp[2] Kraj 103,022,951 bp[2]
Ontologija gena Molekularna funkcija • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • signal transducer activity • histone deacetylase activity • histone deacetylase binding Ćelijska komponenta • citoplazma • transcription repressor complex • nukleoplazma • jedro Biološki proces • positive regulation of I-kappaB kinase/NF-kappaB signaling • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0072468 Transdukcija signala • histone deacetylation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	57708	71148
Ensembl	ENSG00000198160	ENSMUSG00000028522
UniProt	Q8N108	Q5UAK0
RefSeq (mRNK)	NM_001077700 NM_001077701 NM_001077702 NM_001077703 NM_001077704 NM_001146110 NM_001146111 NM_001146112 NM_001146113 NM_001278215 NM_020948 NM_001350530	NM_001039081 NM_001286221 NM_001286222 NM_001286223 NM_027696
RefSeq (bjelančevina)	NP_001071168 NP_001071169 NP_001071170 NP_001071171 NP_001071172 NP_001139582 NP_001139583 NP_001139584 NP_001139585 NP_001265144 NP_065999 NP_001337459	NP_001034170 NP_001273150 NP_001273151 NP_001273152 NP_081972 NP_001391009 NP_001391010 NP_001391011 NP_001391013 NP_001391014
Lokacija (UCSC)	Chr 1: 66.92 – 66.99 Mb	Chr 4: 102.97 – 103.02 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 512 aminokiselina, a molekulska težina 57.983 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAEPSVESSS		PGGSATSDDH		EFDPSADMLV		HDFDDERTLE		EEEMMEGETN
FSSEIEDLAR		EGDMPIHELL		SLYGYGSTVR		LPEEDEEEEE		EEEEGEDDED
ADNDDNSGCS		GENKEENIKD		SSGQEDETQS		SNDDPSQSVA		SQDAQEIIRP
RRCKYFDTNS		EVEEESEEDE		DYIPSEDWKK		EIMVGSMFQA		EIPVGICRYK
ENEKVYENDD		QLLWDPEYLP		EDKVIIFLKD		ASRRTGDEKG		VEAIPEGSHI
KDNEQALYEL		VKCNFDTEEA		LRRLRFNVKA		AREELSVWTE		EECRNFEQGL
KAYGKDFHLI		QANKVRTRSV		GECVAFYYMW		KKSERYDFFA		QQTRFGKKKY
NLHPGVTDYM		DRLLDESESA		ASSRAPSPPP		TASNSSNSQS		EKEDGTVSTA
NQNGVSSNGP		GEILNKEEVK		VEGLHINGPT		GGNKKPLHAD		MDTNGYETDN
LTTDPKLAHM		TARNENDFDE		KSERPAKRRR		VNSNGKESPG		SSEFFQEAVS
HGKFEELENT		DD

Interakcije

Pokazalo se da je MIER1 u interakciji sa HDAC1.^[6]