WFS1

WFS1
Identifikatori
Aliasi	WFS1
Vanjski ID-jevi	OMIM: 606201 MGI: 1328355 HomoloGene: 4380 GeneCards: WFS1
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	6,303,265 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	37,146,549 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• ATPase binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ubiquitin protein ligase binding; • calcium-dependent protein binding; • calmodulin binding; • proteasome binding;
Ćelijska komponenta	• integral component of membrane; • endoplasmic reticulum membrane; • membrana; • integral component of endoplasmic reticulum membrane; • dendrit; • Endoplazmatski retikulum; • Proteasom; • endoplasmic reticulum lumen; • integral component of synaptic vesicle membrane;
Biološki proces	• GO:1904089 negative regulation of neuron apoptotic process; • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • calcium ion homeostasis; • glucose homeostasis; • Nefrogeneza; • protein stabilization; • nervous system process; • positive regulation of growth; • GO:1901227 negative regulation of transcription by RNA polymerase II; • sluh; • endoplasmic reticulum calcium ion homeostasis; • protein maturation by protein folding; • negative regulation of ATF6-mediated unfolded protein response; • negative regulation of DNA-binding transcription factor activity; • response to endoplasmic reticulum stress; • ER overload response; • IRE1-mediated unfolded protein response; • ubiquitin-dependent ERAD pathway; • renal water homeostasis; • negative regulation of programmed cell death; • positive regulation of protein ubiquitination; • negative regulation of type B pancreatic cell apoptotic process; • Vid; • positive regulation of calcium ion transport; • pancreas development; • endoplasmic reticulum unfolded protein response; • olfactory behavior; • Posttranslacione modifikacije;
	Izvori:Amigo / QuickGO
Ortolozi
	7466
	22393
	ENSG00000109501
	ENSMUSG00000039474
	O76024
	P56695
	NM_006005; NM_001145853
	NM_011716
	NP_001139325; NP_005996
	NP_035846
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Volframin jest protein koji je kod ljudi kodiran genom WFS1 sa hromosoma 4.^[5]^[6]^[7]

Kratke činjenice Identifikatori, Aliasi ...

[5]

[6]

[7]

[1]

[2]

[3]

[4]

10	20	30	40	50
MDSNTAPLGP	SCPQPPPAPQ	PQARSRLNAT	ASLEQERSER	PRAPGPQAGP
GPGVRDAAAP	AEPQAQHTRS	RERADGTGPT	KGDMEIPFEE	VLERAKAGDP
KAQTEVGKHY	LQLAGDTDEE	LNSCTAVDWL	VLAAKQGRRE	AVKLLRRCLA
DRRGITSENE	REVRQLSSET	DLERAVRKAA	LVMYWKLNPK	KKKQVAVAEL
LENVGQVNEH	DGGAQPGPVP	KSLQKQRRML	ERLVSSESKN	YIALDDFVEI
TKKYAKGVIP	SSLFLQDDED	DDELAGKSPE	DLPLRLKVVK	YPLHAIMEIK
EYLIDMASRA	GMHWLSTIIP	THHINALIFF	FIVSNLTIDF	FAFFIPLVIF
YLSFISMVIC	TLKVFQDSKA	WENFRTLTDL	LLRFEPNLDV	EQAEVNFGWN
HLEPYAHFLL	SVFFVIFSFP	IASKDCIPCS	ELAVITGFFT	VTSYLSLSTH
AEPYTRRALA	TEVTAGLLSL	LPSMPLNWPY	LKVLGQTFIT	VPVGHLVVLN
VSVPCLLYVY	LLYLFFRMAQ	LRNFKGTYCY	LVPYLVCFMW	CELSVVILLE
STGLGLLRAS	IGYFLFLFAL	PILVAGLALV	GVLQFARWFT	SLELTKIAVT
VAVCSVPLLL	RWWTKASFSV	VGMVKSLTRS	SMVKLILVWL	TAIVLFCWFY
VYRSEGMKVY	NSTLTWQQYG	ALCGPRAWKE	TNMARTQILC	SHLEGHRVTW
TGRFKYVRVT	DIDNSAESAI	NMLPFFIGDW	MRCLYGEAYP	ACSPGNTSTA
EEELCRLKLL	AKHPCHIKKF	DRYKFEITVG	MPFSSGADGS	RSREEDDVTK
DIVLRASSEF	KSVLLSLRQG	SLIEFSTILE	GRLGSKWPVF	ELKAISCLNC
MAQLSPTRRH	VKIEHDWRST	VHGAVKFAFD	FFFFPFLSAA

WFS1

Aminokiselinska sekvenca

Funkcija

Klinički značaj

Reference

Dopunska literatura

Vanjski linkovi

Wikiwand - on