Ljudski ARG1 jest ljudski gen koji kodira protein arginaza.[5]
Kratke činjenice Dostupne strukture, PDB ...
ARG1 |
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Dostupne strukture |
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PDB | Pretraga ortologa: PDBe RCSB |
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Spisak PDB ID kodova |
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1WVA, 1WVB, 2AEB, 2PHA, 2PHO, 2PLL, 2ZAV, 3DJ8, 3E6K, 3E6V, 3F80, 3GMZ, 3GN0, 3KV2, 3LP4, 3LP7, 3MFV, 3MFW, 3MJL, 3SJT, 3SKK, 3TF3, 3TH7, 3THE, 3THH, 3THJ, 4FCI, 4FCK, 4GSM, 4GSV, 4GSZ, 4GWC, 4GWD, 4HWW, 4HXQ, 4IE1 |
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Identifikatori |
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Aliasi | ARG1 |
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Vanjski ID-jevi | OMIM: 608313 MGI: 88070 HomoloGene: 29 GeneCards: ARG1 |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 6: 131.47 – 131.58 Mb | Chr 10: 24.79 – 24.8 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 322 aminokiseline, а molekulska težina 34.735 Da.[6]
10 | | 20 | | 30 | | 40 | | 50 |
MSAKSRTIGI | | IGAPFSKGQP | | RGGVEEGPTV | | LRKAGLLEKL | | KEQECDVKDY |
GDLPFADIPN | | DSPFQIVKNP | | RSVGKASEQL | | AGKVAEVKKN | | GRISLVLGGD |
HSLAIGSISG | | HARVHPDLGV | | IWVDAHTDIN | | TPLTTTSGNL | | HGQPVSFLLK |
ELKGKIPDVP | | GFSWVTPCIS | | AKDIVYIGLR | | DVDPGEHYIL | | KTLGIKYFSM |
TEVDRLGIGK | | VMEETLSYLL | | GRKKRPIHLS | | FDVDGLDPSF | | TPATGTPVVG |
GLTYREGLYI | | TEEIYKTGLL | | SGLDIMEVNP | | SLGKTPEEVT | | RTVNTAVAIT |
LACFGLAREG | | NHKPIDYLNP | | PK |
Arginaza katalizira hidrolizu arginina do ornitina i ureje. Najmanje dvije izoforme sisarske arginaze postoje (tipovi I i II) koje se razlikuju po tkivnoj distribuciji subćelijske lokalizacije, imunskoj unakrsnoj reaktivnosti i fiziološkoj funkciji. Izoforma tipa I kodirana ovim genom je citosolni enzim i eksprimira se pretežno u jetri, kao komponenta ciklusa ureje. Nasljedni nedostatak ovog enzima rezultira argininemijom, autosomno recesivnim poremećajem koju karakterizira hiperamonemija. Za ovaj gen su pronađene dvije varijante transkripta koje kodiraju različite izoforme.[7]
- Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT (juli 2005). "Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease". JAMA. 294 (1): 81–90. doi:10.1001/jama.294.1.81. PMC 2065861. PMID 15998894.
- Jiang M, Ding Y, Su Y, Hu X, Li J, Zhang Z (decembar 2006). "Arginase-flotillin interaction brings arginase to red blood cell membrane". FEBS Letters. 580 (28–29): 6561–4. doi:10.1016/j.febslet.2006.11.003. PMID 17113085. S2CID 20180459.
- Morris SM (juli 2009). "Recent advances in arginine metabolism: roles and regulation of the arginases". British Journal of Pharmacology. 157 (6): 922–30. doi:10.1111/j.1476-5381.2009.00278.x. PMC 2737650. PMID 19508396.
- Rotondo R, Bertolotto M, Barisione G, Astigiano S, Mandruzzato S, Ottonello L, Dallegri F, Bronte V, Ferrini S, Barbieri O (maj 2011). "Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation". Journal of Leukocyte Biology. 89 (5): 721–7. doi:10.1189/jlb.1109737. PMID 21330347. S2CID 25335372.
- Shapiro MB, Senapathy P (septembar 1987). "RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression". Nucleic Acids Research. 15 (17): 7155–74. doi:10.1093/nar/15.17.7155. PMC 306199. PMID 3658675.
- Rotondo R, Barisione G, Mastracci L, Grossi F, Orengo AM, Costa R, Truini M, Fabbi M, Ferrini S, Barbieri O (august 2009). "IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer". International Journal of Cancer. 125 (4): 887–93. doi:10.1002/ijc.24448. PMID 19431148. S2CID 205937936.
- Salam MT, Bastain TM, Rappaport EB, Islam T, Berhane K, Gauderman WJ, Gilliland FD (mart 2011). "Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children". Allergy. 66 (3): 412–9. doi:10.1111/j.1398-9995.2010.02492.x. PMC 3058253. PMID 21039601.
- Gannon PO, Godin-Ethier J, Hassler M, Delvoye N, Aversa M, Poisson AO, Péant B, Alam Fahmy M, Saad F, Lapointe R, Mes-Masson AM (august 2010). Creighton C (ured.). "Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer". PLOS ONE. 5 (8): e12107. Bibcode:2010PLoSO...512107G. doi:10.1371/journal.pone.0012107. PMC 2920336. PMID 20711410.
- Ishikawa T, Harada T, Koi H, Kubota T, Azuma H, Aso T (2007). "Identification of arginase in human placental villi". Placenta. 28 (2–3): 133–8. doi:10.1016/j.placenta.2006.03.015. PMID 16720041.