PSEN2

PSEN2
Identifikatori
Aliasi	PSEN2
Vanjski ID-jevi	OMIM: 600759 MGI: 109284 HomoloGene: 386 GeneCards: PSEN2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	226,927,726 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	180,091,003 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• endopeptidase activity; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • aspartic endopeptidase activity, intramembrane cleaving; • aspartic-type endopeptidase activity;
Ćelijska komponenta	• integral component of membrane; • centrosom; • Golđijev aparat; • endoplasmic reticulum membrane; • membrana; • Golđijeva membrana; • ćelijska membrana; • integral component of plasma membrane; • soma; • nuclear inner membrane; • Z discdkac; • Endoplazmatski retikulum; • perinuklearno područje citoplazme; • kinetohor; • mitochondrial inner membrane; • lysosomal membrane; • cell cortex; • cell surface; • Akson; • growth cone; • Nervno-mišićna veza; • ciliary rootlet; • dendritic shaft; • Lipidni splav; • jedro; • early endosome; • Sinapsna vezikula; • apical plasma membrane; • GO:0009327 makromolekulani kompleks; • synaptic membrane; • integral component of presynaptic membrane; • intracellular anatomical structure;
Biološki proces	• Notch signaling pathway; • GO:0007243 intracellular signal transduction; • response to hypoxia; • ephrin receptor signaling pathway; • protein processing; • GO:0048554 positive regulation of catalytic activity; • negative regulation of apoptotic process; • amyloid-beta metabolic process; • Proteoliza; • membrane protein ectodomain proteolysis; • membrane protein intracellular domain proteolysis; • positive regulation of apoptotic process; • Notch receptor processing; • calcium ion transport; • amyloid precursor protein catabolic process; • Notch receptor processing, ligand-dependent; • regulation of calcium import into the mitochondrion; • mitochondrion-endoplasmic reticulum membrane tethering;
	Izvori:Amigo / QuickGO
Ortolozi
	5664
	19165
	ENSG00000143801
	ENSMUSG00000010609
	P49810
	Q61144
	NM_000447; NM_012486
	NM_001128605; NM_011183
	NP_000438; NP_036618
	NP_001122077; NP_035313
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Presenilin-2 jest protein koji je kod ljudi kodiran genom PSEN2 sa hromosoma 1.^[5]

Kratke činjenice Identifikatori, Aliasi ...

[5]

[1]

[2]

[3]

[4]

10	20	30	40	50
MLTFMASDSE	EEVCDERTSL	MSAESPTPRS	CQEGRQGPED	GENTAQWRSQ
ENEEDGEEDP	DRYVCSGVPG	RPPGLEEELT	LKYGAKHVIM	LFVPVTLCMI
VVVATIKSVR	FYTEKNGQLI	YTPFTEDTPS	VGQRLLNSVL	NTLIMISVIV
VMTIFLVVLY	KYRCYKFIHG	WLIMSSLMLL	FLFTYIYLGE	VLKTYNVAMD
YPTLLLTVWN	FGAVGMVCIH	WKGPLVLQQA	YLIMISALMA	LVFIKYLPEW
SAWVILGAIS	VYDLVAVLCP	KGPLRMLVET	AQERNEPIFP	ALIYSSAMVW
TVGMAKLDPS	SQGALQLPYD	PEMEEDSYDS	FGEPSYPEVF	EPPLTGYPGE
ELEEEEERGV	KLGLGDFIFY	SVLVGKAAAT	GSGDWNTTLA	CFVAILIGLC
LTLLLLAVFK	KALPALPISI	TFGLIFYFST	DNLVRPFMDT	LASHQLYI

PSEN2

Aminokiselinska sekvenca

Funkcija

Interakcije

Reference

Dopunska literatura

Vanjski linkovi

Wikiwand - on