Short-chain dehydrogenase

The short-chain dehydrogenases/reductases family (SDR)^[2] is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called^[3][4][5] 'insect-type', or 'short-chain' alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains,^[6] the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains.^[6]

short chain dehydrogenase
[1]
Identifiers
Symbol	adh_short
Pfam	PF00106
InterPro	IPR002198
PROSITE	PDOC00060
SCOP2	1hdc / SCOPe / SUPFAM
OPM superfamily	119
OPM protein	1xu7
CDD	cd02266
Membranome	246
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Subfamilies

• Glucose/ribitol dehydrogenase InterPro: IPR002347
• Insect alcohol dehydrogenase family InterPro: IPR002424
• 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase InterPro: IPR003560

Human proteins containing this domain

BDH1; BDH2; CBR1; CBR3; CBR4; DCXR; DECR1; DECR2; DHRS1; DHRS10; DHRS13; DHRS2; DHRS3; DHRS4; DHRS4L2; DHRS7; DHRS7B; DHRS8; DHRS9; DHRSX; FASN; FVT1; HADH2; HPGD; HSD11B1; HSD11B2; HSD17B1; HSD17B10; HSD17B12; HSD17B13; HSD17B2; HSD17B3; HSD17B4; HSD17B6; HSD17B7; HSD17B7P2; HSD17B8; HSDL1; HSDL2; PECR; QDPR; RDH10; RDH11; RDH12; RDH13; RDH14; RDH16; RDH5; RDH8; RDHE2; RDHS; SCDR10; SPR; WWOX;