ESR1

ESR1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1A52, 1ERE, 1ERR, 1G50, 1GWQ, 1GWR, 1HCP, 1HCQ, 1L2I, 1PCG, 1QKT, 1QKU, 1R5K, 1SJ0, 1UOM, 1X7E, 1X7R, 1XP1, 1XP6, 1XP9, 1XPC, 1XQC, 1YIM, 1YIN, 1ZKY, 2AYR, 2B1V, 2B1Z, 2B23, 2BJ4, 2FAI, 2G44, 2G5O, 2I0J, 2IOG, 2IOK, 2JF9, 2JFA, 2LLO, 2LLQ, 2OCF, 2OUZ, 2P15, 2POG, 2Q6J, 2Q70, 2QA6, 2QA8, 2QAB, 2QE4, 2QGT, 2QGW, 2QH6, 2QR9, 2QSE, 2QXM, 2QXS, 2QZO, 2R6W, 2R6Y, 2YAT, 2YJA, 3CBM, 3CBO, 3CBP, 3DT3, 3ERD, 3ERT, 3HLV, 3HM1, 3L03, 3OS8, 3OS9, 3OSA, 3Q95, 3Q97, 3UU7, 3UUA, 3UUC, 3UUD, 4AA6, 4DMA, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 4JC3, 4JDD, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4O6F, 4PP6, 4PPP, 4PPS, 4PXM, 4Q13, 4Q50, 4TUZ, 4TV1, 5AK2, 5AAV, 5ACC, 5AAU, 4XI3, 4ZN9, 5FQS, 5FQR, 5FQP, 5FQT, 5FQV, 4ZN7, 5E0W, 5DUG, 4ZUC, 5DXK, 5E19, 5DXQ, 5EI1, 5DXR, 5DVS, 5DZ1, 5E0X, 5DKB, 5DWI, 5E14, 5DXB, 5BPR, 5EIT, 5E15, 4ZNS, 5EGV, 5DL4, 5DWE, 4ZNT, 5EHJ, 5DYD, 5DWG, 4ZNV, 5DWJ, 5DID, 4ZUB, 5BNU, 5DMC, 5DK9, 5DIG, 5DUH, 5DKS, 5DMF, 5DU5, 5DY8, 4ZWH, 5DVV, 5DLR, 4ZWK, 5DRM, 5DP0, 5DKE, 5DZI, 5DZ3, 4ZNU, 5DIE, 5DZ0, 5E1C, 5HYR, 5BQ4, 4ZNW, 5DUE, 5DTV, 5DRJ, 5DKG, 4ZNH, 5BP6, 5DXG, 5DI7, 5DX3, 5DYB, 5DXP, 5DZH, 5DXM
Identifikatori
Aliasi	ESR1
Vanjski ID-jevi	OMIM: 133430 MGI: 1352467 HomoloGene: 47906 GeneCards: ESR1
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	152,129,619 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	4,955,614 bp
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • nitric-oxide synthase regulator activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • estrogen response element binding; • transcription factor binding; • vezivanje iona metala; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • steroid hormone receptor activity; • steroid binding; • beta-catenin binding; • vezivanje iona cinka; • chromatin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa DNK; • sequence-specific DNA binding; • ATPase binding; • vezivanje identičnih proteina; • lipid binding; • core promoter sequence-specific DNA binding; • vezivanje enzima; • protein kinase binding; • TFIIB-class transcription factor binding; • TBP-class protein binding; • estrogen receptor activity; • estrogen receptor binding; • transcription coactivator binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• citoplazma; • membrana; • jedro; • integral component of membrane; • Golđijev aparat; • ćelijska membrana; • nukleoplazma; • transcription preinitiation complex; • citosol; • GO:0009327 makromolekulani kompleks;
Biološki proces	• epithelial cell development; • positive regulation of phospholipase C activity; • mammary gland alveolus development; • transcription by RNA polymerase II; • phospholipase C-activating G protein-coupled receptor signaling pathway; • epithelial cell proliferation involved in mammary gland duct elongation; • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; • protein localization to chromatin; • steroid hormone mediated signaling pathway; • regulation of apoptotic process; • chromatin remodeling; • GO:0009373 regulation of transcription, DNA-templated; • androgen metabolic process; • positive regulation of fibroblast proliferation; • mammary gland branching involved in pregnancy; • negative regulation of gene expression; • transcription, DNA-templated; • negative regulation of DNA-binding transcription factor activity; • cellular response to estrogen stimulus; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of nitric-oxide synthase activity; • transcription initiation from RNA polymerase II promoter; • regulation of branching involved in prostate gland morphogenesis; • male gonad development; • positive regulation of DNA-binding transcription factor activity; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • negative regulation of production of miRNAs involved in gene silencing by miRNA; • response to estrogen; • uterus development; • prostate epithelial cord elongation; • antral ovarian follicle growth; • vagina development; • positive regulation of cytosolic calcium ion concentration; • positive regulation of nitric oxide biosynthetic process; • GO:0072468 Transdukcija signala; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • intracellular steroid hormone receptor signaling pathway; • regulation of inflammatory response; • response to estradiol; • regulation of toll-like receptor signaling pathway; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • protein deubiquitination; • cellular response to estradiol stimulus; • intracellular estrogen receptor signaling pathway; • positive regulation of RNA polymerase II transcription preinitiation complex assembly; • stem cell differentiation; • regulation of Wnt signaling pathway; • regulation of intracellular estrogen receptor signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of protein kinase B signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	2099
	13982
	ENSG00000091831
	ENSMUSG00000019768
	P03372
	P19785
NM_000125; NM_001122740; NM_001122741; NM_001122742; NM_001291230;
	NM_001291241; NM_001328100; NM_001385568; NM_001385569; NM_001385570; NM_001385571; NM_001385572
	NM_007956; NM_001302531; NM_001302532; NM_001302533
NP_000116; NP_001116212; NP_001116213; NP_001116214; NP_001278159;
	NP_001278170; NP_001315029
	NP_001289460; NP_001289461; NP_001289462; NP_031982
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Estrogeni receptor alfa (ERα), znan i kao NR3A1 (član 1grupe A potporodice jedarnih receptora), jedan je od dva tipa estrogenih receptora, jedarni receptor koji se aktivira spolnim hormonom estrogenom. Kod ljudi kodiran genom ESR1 (Estrogeni receptor 1).^[5]^[6]^[7]

Kratke činjenice Dostupne strukture, PDB ...

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10	20	30	40	50
MTMTLHTKAS	GMALLHQIQG	NELEPLNRPQ	LKIPLERPLG	EVYLDSSKPA
VYNYPEGAAY	EFNAAAAANA	QVYGQTGLPY	GPGSEAAAFG	SNGLGGFPPL
NSVSPSPLML	LHPPPQLSPF	LQPHGQQVPY	YLENEPSGYT	VREAGPPAFY
RPNSDNRRQG	GRERLASTND	KGSMAMESAK	ETRYCAVCND	YASGYHYGVW
SCEGCKAFFK	RSIQGHNDYM	CPATNQCTID	KNRRKSCQAC	RLRKCYEVGM
MKGGIRKDRR	GGRMLKHKRQ	RDDGEGRGEV	GSAGDMRAAN	LWPSPLMIKR
SKKNSLALSL	TADQMVSALL	DAEPPILYSE	YDPTRPFSEA	SMMGLLTNLA
DRELVHMINW	AKRVPGFVDL	TLHDQVHLLE	CAWLEILMIG	LVWRSMEHPG
KLLFAPNLLL	DRNQGKCVEG	MVEIFDMLLA	TSSRFRMMNL	QGEEFVCLKS
IILLNSGVYT	FLSSTLKSLE	EKDHIHRVLD	KITDTLIHLM	AKAGLTLQQQ
HQRLAQLLLI	LSHIRHMSNK	GMEHLYSMKC	KNVVPLYDLL	LEMLDAHRLH
APTSRGGASV	EETDQSHLAT	AGSTSSHSLQ	KYYITGEAEG	FPATV

ESR1

Aminokiselinska sekvenca

Struktura

Ligandi

Agonisti

Neselektivni

Selektivni

Mješoviti

Antagonisti

Neselektivni

Selektivni

Afiniteti

Tkivna distribucija i funkcija

Klinički značaj

Koaktivatori

Interakcije

Reference

Dopunska literatura

Vanjski linkovi

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